CNR2

(redirected from cannabinoid receptor 2)

CNR2

A gene on chromosome 1p36.11 that encodes one of two cannabinoid receptors, which belong to the G protein-coupled receptor family. CNR2 inhibits adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner, and is responsible for cannabinoid-induced CNS effects (e.g., effects on mood and cognition) of marijuana. CNR2 may play a role in the inflammatory response, nociceptive transmission and in bone homeostasis. CNR2 is also a less preferred gene symbol for what is now designated as PCDHA6, see there.
References in periodicals archive ?
Sinai reported that agonists of Cannabinoid Receptor 2 (CB2) reduced infection in primary CD4+ T cells following cell-free and cell-to-cell transmission of CXCR4-tropic HIV.
Cannabinoids may control the growth of human cancers, in part, through the cannabinoid receptor 2 gene (CNR2), which emerged as the best-connected "super hub" in an inferred large-scale association network for breast cancer data (Schafer & Strimmer 2005).
8,778,950, entitled "Cannabinoid Receptor Modulators," by the United States Patent and Trademark Office for APD371, an agonist of the cannabinoid receptor 2 (CB2).