CNR1

(redirected from cannabinoid receptor 1)

CNR1

A gene on chromosome 6q14-q15 that encodes one of two cannabinoid receptors, which belong to the G protein-coupled receptor family. CNR1 inhibits adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner, and is responsible for cannabinoid-induced CNS effects (e.g., effects on mood and cognition) of marijuana. CNR1 is also a less preferred gene symbol for what is now designated as PCDHA4, see there.
References in periodicals archive ?
Blockade of cannabinoid receptor 1 improves insulin resistance, lipid metabolism, and diabetic nephropathy in db/db mice.
Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy.
Cannabinoid Receptor 1 is most recent GPCR to be targeted by RuiYi's iCAPS platform
Bradley Winters, lead author of the research paper and a freshly minted WSU doctor of neuroscience, said he, his major advisor Yan Dong, and colleagues at WSU, the University of Pittsburgh and the European Neuroscience Institute focused on cells that produce a signaling molecule called cannabinoid receptor 1, or CB1.
Also, the psychotropic action of the phytocannabinoid THC was explained by cannabinoid receptor 1 (CB1) binding that was first cloned in 1990 (Hosking and Zajicek 2008).