candidate gene


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A DNA sequence in a chromosome region suspected of being involved in a particular disease of interest, whose protein product suggests that it could be the disease gene in question

candidate gene

(kăn′dĭ-dāt″)
A gene that is suspected of being responsible for a particular trait or illness.

candidate gene

a gene believed to be related to a particular disease or condition. Candidate genes can be identified on the basis of position or function. A positional candidate gene is located in a chromosomal region suspected of being linked to a disease. A functional candidate gene is a gene encoding a product connected with the disease.
References in periodicals archive ?
The molecular functioning of DUB3 therefore presented the gene as a likely novel candidate gene for the KWE phenotype.
Recently, a positional candidate gene on SSC5, PTHLH (parathyroid hormone-like hormone), was investigated for the relationship with teat numbers.
These include (1) multigene panels for a variety of inherited disorders and oncology conditions (2-7); (2) human leukocyte antigen locus characterization (8-10); (3) pathogen genome sequencing for identification and assessment of resistance (11,12); (4) exome sequencing for candidate gene discovery in inherited disorders and characterization of the mutational landscape in tumors (13-16); and (5) whole genome sequencing.
These so-called candidate gene studies have been fruitful in alcohol research.
Amongst RAAS genes studied till date, CYP11B2 gene (CYP11B2) encoding aldosterone synthase has emerged as a strong candidate gene for hypertension.
By using such a relationship, investigators can filter candidate gene lists and focus on those genes that most likely are associated with a causal relationship.
This is the first time someone has identified a candidate gene for autism, replicated their finding, and demonstrated that gene's biological function," remarks geneticist Daniel H.
LANCASTER - Mayoral candidate Gene Gaynor said he filed a police report regarding the theft and vandalism of his campaign signs.
clinical) analysis, correlations with other distinct genetic disorders, and candidate gene analysis.
The human homolog of insect-derived growth factor, CECR1, is a candidate gene for features of cat eye syndrome.
Tuberous Sclerosis (TSC) has been found to be a candidate gene for autism by linkage study analysis and can be found on chromosomes 9q34 (TSC 1) and 16p 13 (TSC 2).
For example, disruption of a candidate gene should abolish the ability of the mutated pathogen to elicit disease in an animal model of infection, and reintroduction of the wild-type gene should reestablish virulence.