candidate gene


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A DNA sequence in a chromosome region suspected of being involved in a particular disease of interest, whose protein product suggests that it could be the disease gene in question

candidate gene

(kăn′dĭ-dāt″)
A gene that is suspected of being responsible for a particular trait or illness.

candidate gene

a gene believed to be related to a particular disease or condition. Candidate genes can be identified on the basis of position or function. A positional candidate gene is located in a chromosomal region suspected of being linked to a disease. A functional candidate gene is a gene encoding a product connected with the disease.
References in periodicals archive ?
It is conceivable that a multi-gene diagnostic sensor chip based on a number of genetic markers including PTHrP as a candidate gene would predictably identify those subjects at risk of developing low bone mass and osteoporosis so that preventive interventions and/or prophylactic therapeutic measures could be instituted early and effectively.
Possible methodologies include, but are not limited to, traditional linkage analysis, sibling pair and affected-pedigree-member methods, case-control or family-based association studies, linkage disequilibrium mapping in genetically isolated populations, candidate gene analysis, cytogenetic studies to identify chromosomal abnormalities associated with a disorder, and positional cloning.
Of particular interest is toll-like receptor 4, a candidate gene for asthma susceptibility.
It is considered to be a candidate gene for the regulation of growth and development in cattle and other mammals (Zhang et al.
Candidate gene ARHGAP24 is a key regulator of angiogenesis through its effects on endothelial cell migration, proliferation and capillary tube formation [22].
It also discusses the role of the environment in disease genetics, all methods of genotyping, genetic risk profiling and the use of genetic associations in medical practice, laboratory aspects of genetic association studies, and candidate gene studies.
Each line contained a specific variant of a single candidate gene that had been implicated in altered activity and development time.
Population based candidate gene studies as well as linkage disequilibrium has been used to identify the etiology of CL/P so as to predict its occurrence and to prevent it from occurring in the future.
The molecular functioning of DUB3 therefore presented the gene as a likely novel candidate gene for the KWE phenotype.
The system supports a range of sequencing applications, including candidate gene screening, Genome Wide Association Study (GWAS) follow up, deep sequencing of heterogeneous tumor samples, medical genetics and targeted methylation analysis.
Amongst RAAS genes studied till date, CYP11B2 gene (CYP11B2) encoding aldosterone synthase has emerged as a strong candidate gene for hypertension.