These findings come from the Diabetic Retinopathy Candesartan
Trials (DIRECT) presented at the annual meeting of the European Association for the Study of Diabetes.
Larger and longer studies are needed to support its promising results concerning the use of candesartan
for migraine prophylaxis.
A total of 5,231 patients, whose average age was 40 years and whose mean duration of diabetes was 9 years, were randomized to placebo or candesartan
at an initial dose of 16 mg/day.
They did not observe any adverse effects of candesartan
use over the course of their study.
The company also expects that it will succeed its current mainstay product candesartan
, also an ARB.
Aggressive antihypertensive therapy based on hydrochlorothiazide, candesartan
or lisinopril as initial choice in hypertensive type II diabetic individuals: effects on albumin excretion, endothelial function and inflammation in a doubleblind, randomized clinical trial.
was obtained from AstraZeneca (Wilmington, DE) as a kind gift.
As a result of the use of candesartan
to treat CHF with LVSD, the NHS in Scotland may save as many as 29,500 bed days each year (data on file).
Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan
and lisinopril microalbuminuria (CALM) study.
Yusuf agreed that two major studies--the Candesartan
in Heart Failure: Assessment of Reduction in Mortality and Morbidity and the Valsartan Heart Failure Trial--have shown clinical benefits for combined ACE inhibitor/ARB therapy in patients with heart failure.
Tveit A, Seljeflot I, Grundvold I, Abdelnoor M, Arnesen H, Smith R Candesartan
, NT-proBNP and recurrence of atrial fibrillation after electrical cardioversion.
cilexetil is an angiotensin II receptor antagonist that is widely used in the treatment of hypertension.