cancer cell


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cancer cell

A malignant cell, which has several key features:
(1) Divide uncontrollably;
(2) Refuse to die—i.e., bypass programmed cell death (apoptosis); and
(3) Spread distally (matastasis) from original site via lymphatics or blood vessels.

cancer cell

A cell present in a neoplasm and differentiated from normal tissue cells because of its degree of anaplasia, irregularity of shape, nuclear size, changes in the structure of the nucleus and cytoplasm, increased number of mitoses, and ability to metastasize.
See also: cell
References in periodicals archive ?
Dr Athos Gianella-Borradori, Cyclacel's medical director commented, "It is encouraging to see validation of the presumed mechanism by which CYC202 is causing the death of cancer cells through biomarker technology.
AR expression or ligand specificity played a minimal role in this arsenic-induced prostate cancer cell progression.
Cancer cells have multiple abnormalities, including DNA damage, but they are able to survive and proliferate because key checkpoints and apoptotic pathways are disabled as the cancer develops.
On the basis of these observations, we reasoned that the MCF-7 human breast cancer cell proliferation (the E-Screen) assay (Soto et al.
Normal cells that transform into cancer cells undergo various metabolic changes, including shifts in activities of enzymes that mediate macromolecule synthesis and growth-signaling pathways.
Others transplant tumors or inject millions of cancer cells into the bloodstream.
Her cancer cells seemed to be reactivated in her stressful state.
Lead author Fernando LopezDiaz, Salk staff scientist, said the team aimed to uncover the diversification "switch" by which cancer cells replicated but vary slightly from one another and that turning off this cellular process would strip cancer's ability to survive drug treatment, Science Daily reported.
A single tumor-suppressing gene is a key to understanding--and perhaps killing--dormant ovarian cancer cells that hide out after initial treatment, only to reawaken years later, report researchers at the University of Texas M.
The antibody serves to target the compound specifically to cancer cells and the cytotoxic agent serves to kill those cells.
In 1889, Stephen Paget proposed that cancer cells shed from an initial tumor were dispersed randomly throughout the body by the circulatory system.

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