cancer antigen


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Related to cancer antigen: Cancer antigen 19-9, Cancer antigen 15-3

cancer antigen

Abbreviation: CA
A protein or carbohydrate that is either expressed by cancerous cells but not by healthy cells or is expressed by cancerous cells in much greater concentrations than by healthy cells. Cancer antigens are used in clinical medicine to screen body fluids for tumors or to follow the response of tumors to treatment. Since they stimulate the immune response, they are also used in the manufacture of antitumor vaccines. See: table
Note: several antigens on this list also detect benign diseases and conditions.
Antigen name or designationAbbreviationThe tumor it detects
Alpha-fetoproteinAFPNonseminomatous germ cell tumor
CA 15–3Breast cancer
CA 19–9Pancreatic cancer
CA 50Gastrointestinal tract tumors
CA 125Ovarian/peritoneal cancer
Carcinoembryonic antigenCEAGastrointestinal tract tumors and tumors of solid internal organs
Human chorionic gonadotropinHCGNonseminomatous germ cell tumors; choriocarcinoma
Microglobulin-beta 2 subunitb2–MMultiple myeloma
Neuron-specific enolaseNSEBroad variety of cancers, including small cell carcinoma of lung
NY-BR-40 and othersBreast cancer
Prostate specific antigenPSAProstate cancer
Urinary tumor associated antigenUTAAMelanoma
See also: antigen
References in periodicals archive ?
Family 2 is directed to cancer antigens believed to be capable of stimulating anti-cancer immune responses.
8] Nonstandard abbreviations: CEA, carcinoembryonic antigen; PSA, prostate-specific antigen; CA125, cancer antigen 125; CA19-9, cancer antigen 19-9; BCG, bacille Calmette-Guerin; ADCC, antibody-dependent cell-mediated cytotoxicity; OC125, ovarian cancer 125; CA125II, heterologous double-determinant CA125 assay; FDA, US Food and Drug Administration; ROMA, risk of ovarian malignancy algorithm; HE4, human epididymis protein 4; PPV, positive predictive value; PLCO, Prostate, Lung, Colon, and Ovary Cancer (Screening Trial); TVS, transvaginal sonography; UKCTOCS, UK Collaborative Trial of Ovarian Cancer Screening; ROCA, Risk of Ovarian Cancer Algorithm; SPORE, Specialized Program of Research Excellence; CEACAM, CEA cell adhesion molecule; USPSTF, US Preventive Services Task Force.
This is the first milestone payment Corixa has received under the terms of a 1999 agreement with JT, which provides JT with certain rights to develop vaccine products containing Corixa's novel lung cancer antigens, including antigens formulated using Corixa's microsphere delivery system and proprietary adjuvant technologies.
We are excited to enter this alliance with Agensys to generate fully human antibody candidates to their large portfolio of novel, clinically relevant cancer antigens," stated R.
Prostate cancer detection in the "grey area" of prostate-specific antigen below 10 ng/ml: head-to-head comparison of the updated PCPT calculator and Chun's nomogram, two risk estimators incorporating prostate cancer antigen 3.
A promising new prostate cancer marker, PCA3 (prostate cancer antigen 3), has recently become available, and its utility for predicting short-term biopsy progression has been studied in an active surveillance program (2).
MIAMI -- A test for circulating lysophosphatidic acid dramatically improves detection of early-stage ovarian cancer, compared with current screening methods dependent on cancer antigen 125, Yan Xu, Ph.
Its lead programme is an affinity enhanced T-cell therapy targeting the NY-ESO cancer antigen.
4] Nonstandard abbreviations: PSA, prostate-specific antigen; EPCA-2, early prostate cancer antigen 2; S/N, signal-to-noise; EDRN, Early Detection Research Network.
Cancer antigen 125 (CA 125) (1-3) is commonly increased in liver cirrhosis and increased even more in ascitic fluid (4-6).
Thus, survivin is considered a major cancer antigen.
Placental alkaline phosphatase and cancer antigen 125 in sera of patients with benign and malignant diseases.