cancer antigen


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Related to cancer antigen: Cancer antigen 19-9, Cancer antigen 15-3

cancer antigen

Abbreviation: CA
A protein or carbohydrate that is either expressed by cancerous cells but not by healthy cells or is expressed by cancerous cells in much greater concentrations than by healthy cells. Cancer antigens are used in clinical medicine to screen body fluids for tumors or to follow the response of tumors to treatment. Since they stimulate the immune response, they are also used in the manufacture of antitumor vaccines. See: table
Note: several antigens on this list also detect benign diseases and conditions.
Antigen name or designationAbbreviationThe tumor it detects
Alpha-fetoproteinAFPNonseminomatous germ cell tumor
CA 15–3Breast cancer
CA 19–9Pancreatic cancer
CA 50Gastrointestinal tract tumors
CA 125Ovarian/peritoneal cancer
Carcinoembryonic antigenCEAGastrointestinal tract tumors and tumors of solid internal organs
Human chorionic gonadotropinHCGNonseminomatous germ cell tumors; choriocarcinoma
Microglobulin-beta 2 subunitb2–MMultiple myeloma
Neuron-specific enolaseNSEBroad variety of cancers, including small cell carcinoma of lung
NY-BR-40 and othersBreast cancer
Prostate specific antigenPSAProstate cancer
Urinary tumor associated antigenUTAAMelanoma
See also: antigen
References in periodicals archive ?
At a recent American Society of Clinical Oncology (ASCO) meeting, additional evidence was presented showing that the new test system using a panel of six cancer antigens (p53, NY-ES0-1, CAGE, GBU4-5, Annexin 1, and SOX2), when run on an ELISA platform, was able to detect autoantibodies, or "immuno-biomarkers," to lung cancer.
DCOne-based dendritic cell vaccines, in some indications loaded with cancer antigens for targeted treatment, are used as standardized, therapeutic products.
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co-director of University of Pennsylvania's Rena Rowan Breast Cancer Center and Surgical Director of the immunotherapy program at the Abramson Cancer Center, the technology enables the development of DCs designed to trigger powerful and targeted immune responses to specific cancer antigens.
Vile deployed the human vaccine prostate cancer antigens through the mutated VSV vector to raise a full-on assault from the mice's T-cells.
The candidates vaccines and antibodies identified in this report target 17 different cancer antigens or (antibody) drug targets and these developments are being taken forward by 30 different companies.
ImmunoCellular's pipeline also includes ICT-121, a dendritic cell vaccine targeting CD133, ICT-140, a dendritic cell vaccine targeting ovarian cancer antigens and cancer stem cells and a preclinical antigen-specific T-cell therapy program.
This directly introduces the attached cancer antigens inside the immune system cells.
Yvonne Paterson of the University of Pennsylvania has developed a promising immunotherapeutic platform and technology that lends itself to delivering immune triggers against a number of cancer antigens.
National Cancer Institute (NCI) Study Published in Science Used PGDx Exome Sequencing to Identify Epithelial Cancer Antigens with Demonstrated Immunotherapy Potential--
These candidate breast cancer vaccines and antibodies target 17 cancer antigens or antibody targets, and are being taken forward by 30 companies.