However, 4 samples (18%) had antibody to canarypox
virus antigen with test sample and negative control ratios (P/N values) ranging from 2.
Modified vaccinia ankara (MVA), canarypox
, adenovirus and adeno-associated virus (AAV) are among the commonly used vectors in HIV vaccines currently under clinical development.
Vaccine recipients received, over a 6-month period, four doses of a canarypox
The priming vaccine, Sanofi Pasteur's ALVAC-HIV, is a modified canarypox
ALVAC uses canarypox
, a bird virus altered so it can't cause human disease, to ferry synthetic versions of three HIV genes into the body.
It makes use of a modified canarypox
virus, ALVAC(2), which has been shown in an extensive body of research to promote immune responses in humans.
Their topics include an immunological basis for the rational design of new vaccines, new approaches to immunization using the skin, veterinary applications of the canarypox
vaccine vector technology in domestic mammalian species, human papillomavirus, the current status of cancer vaccines, and antigen-specific immunotherapy for allergies.
During this same timeframe, with mounting evidence suggesting that CDV played a role, the IWS began a vaccination trial using an experimental CDV recombinant vaccine that utilized a canarypox
virus as a vector (Timm et al.
Macaque dendritic cells infected with SIV-recombinant canarypox
ex vivo induce SIV-specific immune responses in vivo," AIDS Research and Human Retroviruses 20(8): 871-884.
Some of the work that has been done so far involves a recombinant canarypox
vaccine (vCP1452) carrying specific HIV genes (env, gag, nef, and pol) with recombinant gp 160.
Two vaccines are available for vaccinating equines: an inactivated WNV vaccine and a recombinant vaccine that uses canarypox
virus to express WNV antigens (44,45).
BOSTON -- An interferon-[alpha] agent and a recombinant canarypox
vaccine are among the latest experimental therapies to control HIV replication in clinical studies by boosting the immune system.