camptothecins

camp·to·the·cins

(kamp'tō-thek'inz),
1. Antitumor agents acting as topoisomerase inhibitors; include irinotecan and topotecan.
2. A semisynthetic drug derived from camptothecin.

camptothecins

A new class of cytotoxic anticancer drugs based on the plant alkaloid camptothecin found in the wood, bark and fruit of the tree Camptotheca acuminata . Camptopthecins attack the enzyme TOPOISOMERASE. The class includes the drugs TOPOTECAN and IRINOTECAN both of which are showing promising results in the treatment of small cell lung cancer and ovarian cancer.
References in periodicals archive ?
These proteins are members of the ATP-binding family of drug efflux proteins that are implicated in resistance to camptothecins.
We have already shown that the polymer can make other cancer drugs like camptothecins more effective as well, providing a broad technology platform for extending our vertically integrated oncology pipeline.
Due to the severe side effects and difficulty in formulation associated with the most active camptothecins, their full therapeutic potential has never been realized.
Within drug subcategories, the fastest growing sectors were anticancer biologicals and the novel topoisomerase I inhibitor camptothecins.
Camptothecins are the second fastest growing class of anti-cancer drugs in the U.
cti) (Nasdaq: CTIC) report on preclinical studies demonstrating the ability to link a potent class of anticancer drugs called camptothecins to polyglutamate (PG) resulting in a water-soluble, less toxic, and more effective version of the drug.
Karenitecin has been specifically crafted to overcome known problems of commercially available camptothecins such as lack of oral bioavailability, lactone instability, toxicity, unfavorable metabolism and drug resistance.
As part of this agreement, SuperGen also secured the global rights to other camptothecins and additional anticancer compounds, one of which has already demonstrated marked antitumor activity and is expected to have a very favorable safety profile.
The camptothecins definitely bind to topoisomerase I and stabilize DNA-topoisomerase I cleavable complex.
Camptothecins interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks.