These proteins are members of the ATP-binding family of drug efflux proteins that are implicated in resistance to camptothecins
We have already shown that the polymer can make other cancer drugs like camptothecins
more effective as well, providing a broad technology platform for extending our vertically integrated oncology pipeline.
Karenitecin BNP1350 is a member of a new class of lipophilic camptothecins
discovered and developed by BioNumerik.
Due to the severe side effects and difficulty in formulation associated with the most active camptothecins
, their full therapeutic potential has never been realized.
Within drug subcategories, the fastest growing sectors were anticancer biologicals and the novel topoisomerase I inhibitor camptothecins
are the second fastest growing class of anti-cancer drugs in the U.
cti) (Nasdaq: CTIC) report on preclinical studies demonstrating the ability to link a potent class of anticancer drugs called camptothecins
to polyglutamate (PG) resulting in a water-soluble, less toxic, and more effective version of the drug.
Karenitecin has been specifically crafted to overcome known problems of commercially available camptothecins
such as lack of oral bioavailability, lactone instability, toxicity, unfavorable metabolism and drug resistance.
To Inhaled Versions of All Camptothecins
As part of this agreement, SuperGen also secured the global rights to other camptothecins
and additional anticancer compounds, one of which has already demonstrated marked antitumor activity and is expected to have a very favorable safety profile.
definitely bind to topoisomerase I and stabilize DNA-topoisomerase I cleavable complex.
interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks.