camptothecins

camp·to·the·cins

(kamp'tō-thek'inz),
1. Antitumor agents acting as topoisomerase inhibitors; include irinotecan and topotecan.
2. A semisynthetic drug derived from camptothecin.

camptothecins

A new class of cytotoxic anticancer drugs based on the plant alkaloid camptothecin found in the wood, bark and fruit of the tree Camptotheca acuminata . Camptopthecins attack the enzyme TOPOISOMERASE. The class includes the drugs TOPOTECAN and IRINOTECAN both of which are showing promising results in the treatment of small cell lung cancer and ovarian cancer.
References in periodicals archive ?
The camptothecins definitely bind to topoisomerase I and stabilize DNA-topoisomerase I cleavable complex.
Cheng used a chemical linker to attach the camptothecins to the polymer.
Prior to this discovery, most cancer drugs have targeted binding to the major groove in DNA leading to the successful introduction of several new classes of anticancer drugs, including topoisomerase inhibitors such as camptothecins and anthracyclines.
An up-to-date summary is offered including a discussion of topoisomerase I, along with an analysis of animal models for defining the anticancer potential of camptothecins, and issues of camptothecin resistance.
Karenitecin is in the drug class known as camptothecins and has been designed to avoid problems with oral bioavailability, unfavorable metabolism, toxicity and drug resistance that have been associated with other camptothecins.
The camptothecins stop cells from completing mitosis, specifically in the S-phase.
Topoisomerase inhibitors that inhibit either topoisomerase I or II are used to treat a number of different tumor types: camptothecins (topoisomerase I inhibitors) for colorectal cancer; anthracyclines (topoisomerase II inhibitors) for breast, ovarian, bladder cancer and Non Hodgkin's Lymphoma; etoposide (topoisomerase II inhibitor) for lung cancer.