virus; CPXV, cowpox virus; ECTV, ectromelia virus; MPXV, monkeypox virus; OPV, orthopoxvirus; RACV, raccoonpox virus; TATV, taterapox virus; VACV, vaccinia virus; VARV, variola virus.
Rapid non-enzymatic extraction method for isolating PCR-quality camelpox
virus DNA from skin.
Zoonotic poxvirus infections include monkeypox, cowpox, buffalopox, feline cowpox, horsepox, camelpox
, and elephantpox.
Guanine at position 59 is specific for camelpox
virus, and this mismatch could explain the lack of sensitivity obtained with the 14-kD POX probe with this virus.
In 1995 the Iraqi government admitted to UN weapons inspectors that it was working with camelpox
But new research now suggests that camelpox
itself could pose a threat.
1] Nonstandard abbreviations: VAR, variola major virus; MPV, monkeypox virus; CML, camelpox
virus; VAC, vaccinia virus; CPV, cowpox virus; FRET, fluorescence resonance energy transfer; HA, hemagglufinin gene; ENIVD, European Network for the Diagnosis of Imported Viral Diseases; and geq, genome equivalents.
Analysis of the camelpox
virus thymidine kinase gene.
Smallpox, an ancient human scourge of unparalleled destructive importance throughout most of recorded human history (Figure 1), is believed to have emerged in the Middle East some 6,000-10,000 years ago (1,2) from either camelpox
or the gerbil-specific taterapox (3-5).
The resultant phylogenetic tree (Figure 2A) depicts several highly supported clusters including monophyletic VACV, MPXV, VARV, and camelpox
virus (CMLV) assemblages.
The reference cowpox virus strain Brighton grouped with camelpox
and variola viruses instead of other cowpox or vaccinia viruses.
Although the formation of typical A-type inclusions is restricted to cells infected with cowpox virus, ectromelia virus, and raccoonpox virus (2), the sequence coding the N-terminus of the protein is highly conserved in many viruses, including CPXV, VACV, variola virus, camelpox
virus, and ectromelia virus.