On immunohistochemical staining, the tumor cells stained intensely and diffusely for calretinin
(Fig 5), whereas there was no reaction for placental alkaline phosphatase and c-Kit expression.
Expression of CD10, calretinin
, and inhibin has also been described (18); however, morphology remains the most important factor for diagnosis.
Other proteins such as calretinin
, calbindin, and parvalbumin function as localized calcium buffers, especially in the pre- and postsynaptic regions, regulating Ca2+ densities to affect the sensitivity of the neuron to various stresses such as oxidative damage, ischemia, and depolarization.
Inhibin and calretinin
are negative in endometrioid carcinomas and epithelial membrane antigen is positive, distinguishing them from GCTs.
IHC offers several advantages in the workup of HD, including applicability to formalin-fixed paraffin-embedded tissue and pathologists' familiarity interpreting IHC.
They discovered that the immature neuronal marker Calretinin
was significantly increased in both schizophrenia and bipolar disorder groups and mature neuronal marker Calbindin show a trend toward decrease in bipolar disorder patients.
Interestingly, two calcium binding proteins, calretinin
and parvalbumin, that were upregulated in the cerebellum at 24 and 48 h after blast exposures by proteomic analysis were not found to be altered in cDNA microarray analysis at 6 h after blast exposures.
On immunohistochemistry tumor cells were positive for mesothelial marker calretinin
and negative for CD34, factor-VIII and CEA.
The tumor cells stained positive for mesothelial markers calretinin
, keratin 5/6, keratin AE1/3, and CAM 5.
CD99 showed weak cytoplasmic positivity, and smooth muscle actin (SMA), desmin, synaptophysin, chromogranin, S100 protein, cytokeratin AEl/AE3, CD45, CD34, CD117, calretinin
, calponin,13-catenin, epithelial membrane antigen (EMA), and Cam5.
Results: Most frequently used markers were calretinin
and CK5/6 for epithelioid malignant mesothelioma and CEA, CD1 5 and TTF-1 for adenocarcinoma.
The expression of parvalbumin is relatively low in both the central and the basomedial nuclei of the amygdala; the expression of calretinin
and calbindin, however, shows some variation between these nuclei.