calretinin


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CALB2

A gene on chromosome 16q22.2 that encodes a calcium-binding protein of the troponin C superfamily, popularly termed calretinin, which contains 6 active calcium-binding domains and plays a role in various cell functions—e.g., message targeting, intracellular calcium buffering, modulating neuronal excitability.
 
Molecular pathology
CALB2 is used as a marker of Hirschsprung disease and some cancers.

calretinin

(kal-ret′ĭn-ĭn)
A calcium-binding protein used in immunohistochemical studies to identify the presence of neuronal cells or several specific tumors, e.g., malignant mesotheliomas.
References in periodicals archive ?
On immunohistochemical staining, the tumor cells stained intensely and diffusely for calretinin (Fig 5), whereas there was no reaction for placental alkaline phosphatase and c-Kit expression.
Expression of CD10, calretinin, and inhibin has also been described (18); however, morphology remains the most important factor for diagnosis.
Other proteins such as calretinin, calbindin, and parvalbumin function as localized calcium buffers, especially in the pre- and postsynaptic regions, regulating Ca2+ densities to affect the sensitivity of the neuron to various stresses such as oxidative damage, ischemia, and depolarization.
Inhibin and calretinin are negative in endometrioid carcinomas and epithelial membrane antigen is positive, distinguishing them from GCTs.
Calretinin IHC offers several advantages in the workup of HD, including applicability to formalin-fixed paraffin-embedded tissue and pathologists' familiarity interpreting IHC.
They discovered that the immature neuronal marker Calretinin was significantly increased in both schizophrenia and bipolar disorder groups and mature neuronal marker Calbindin show a trend toward decrease in bipolar disorder patients.
Interestingly, two calcium binding proteins, calretinin and parvalbumin, that were upregulated in the cerebellum at 24 and 48 h after blast exposures by proteomic analysis were not found to be altered in cDNA microarray analysis at 6 h after blast exposures.
On immunohistochemistry tumor cells were positive for mesothelial marker calretinin and negative for CD34, factor-VIII and CEA.
The tumor cells stained positive for mesothelial markers calretinin, keratin 5/6, keratin AE1/3, and CAM 5.
CD99 showed weak cytoplasmic positivity, and smooth muscle actin (SMA), desmin, synaptophysin, chromogranin, S100 protein, cytokeratin AEl/AE3, CD45, CD34, CD117, calretinin, calponin,13-catenin, epithelial membrane antigen (EMA), and Cam5.
The expression of parvalbumin is relatively low in both the central and the basomedial nuclei of the amygdala; the expression of calretinin and calbindin, however, shows some variation between these nuclei.