PDE1B

(redirected from calmodulin-stimulated phosphodiesterase PDE1B1)

PDE1B

A gene on chromosome 12q13 that encodes a cyclic nucleotide phosphodiesterase, which plays a critical role in signal transduction, regulating intracellular cyclic nucleotide concentrations by hydrolysing cGMP and cAMP to GMP and AMP. As with other PDE1s, PDE1B is activated by calmodulin in the presence of Ca2+.