calmodulin


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calmodulin

 [kal-mod´u-lin]
a calcium-binding protein present in all nucleated cells, thought to be an essential mediator of most calcium-sensitive cellular processes.

cal·mod·u·lin

(kal-mod'ū-lin),
A small, ubiquitous eukaryotic protein that binds calcium ions, thereby becoming the agent for many of the cellular effects long ascribed to calcium ions. This calcium-protein complex binds to the apoenzyme, to form the holoenzyme, of certain phosphodiesterases; through these mechanisms, the complex regulates adenylate and guanylate cyclases, many kinases, phospholipase A2 activity, and other basic cellular functions.
[calcium + modulate]

calmodulin

/cal·mod·u·lin/ (kal-mod´u-lin) a calcium-binding protein present in all nucleated cells; it mediates a variety of cellular reponses to calcium.

calmodulin

(kăl-mŏj′ə-lĭn)
n.
A calcium-binding protein that mediates many metabolic processes, such as contraction of smooth muscle, by binding to enzymes and other proteins.

calmodulin

[kalmod′yəlin]
a calcium-binding protein that mediates a variety of biochemical and physiological processes, including the contraction of smooth muscles and the release of norepinephrine. Calmodulin may act independently of, in concert with, or antagonistically to reactions involving cyclic adenosine monophosphate.

cal·mod·u·lin

(kal-mod'yū-lin)
A protein that binds calcium ions, thereby becoming the agent for many of the cellular effects long ascribed to calcium ions.
[calcium + modulate]

cal·mod·u·lin

(kal-mod'yū-lin)
Protein that binds calcium ions.
[calcium + modulate]

calmodulin (kalmoj´əlin),

n a calcium-binding protein that mediates a variety of biochemical and physiologic processes, including the contraction of muscles and the release of norepinephrine.

calmodulin

a calcium-binding protein concerned in the response of muscle fibers and other cells to calcium.
References in periodicals archive ?
small Ran-related GTP-binding protein; calmodulin 4 which is a regulatory protein controlled by calcium; nucleoside diphosphate kinase that regulates metabolic pools of nucleoside diphosphates; histones that control chromosome organization; heat-shock proteins that regulate a plant cell's response to stress.
The sensing protein calmodulin is a calcium-activated protein that renders graded changes in the concentration of the calcium ion into graded responses through activation of various enzymatic pathways, including local changes in membrane proteins to modulation of genetic expression.
We discovered that a genetic mutation in calmodulin causes a loss of regular heart rhythm and produces ineffective communication between calmodulin and RYR.
To our great surprise, we found that the calcium pump binds two calmodulin proteins, and not just one as always assumed,' explains Dr Tidow.
02, and the partial sequencing of the nuclear calmodulin gene was based on the amplicon generated by PCR reaction by using CL1 and CL2A primers (2,3).
NO is generated in the neuronal cells as a co-product of the conversion of the semi-essential amino acid L-arginine to L-citrulline by the enzyme nitric oxide synthase (NOS) with calcium and calmodulin as cofactors.
Following the editors' introduction, 24 chapters address functions of biologically active proteins and peptides, including as antioxidants, antihypertensives, calmodulin inhibitors, amyloidogenics, immunotherapy agents for food allergy, and regulators of satiety; examples of food proteins and peptides with biological activity found in a variety of food materials; and recent advances in bioactive peptide analysis for food application.
Supression of lymphocytes mitogenesis by tamoxifen: studies on protein kinase C, calmodulin and calcium.
One of them, calmodulin (CAM), is a multifunctional calcium sensor protein that participates in several cellular processes, such as secretion and metabolism of calcium (Kretschmer & Fritzsche 2004).
Further tests using calmodulin showed the sensor could discriminate between varieties of the protein that take different shapes, according to the multi-disciplinary team of biologists, chemists and physicists.
Some data, however, indicate that the binding affinity of the oppositely charged calcium sensor calmodulin and the target peptide actually increases tenfold with adding NaCl (Andre et al.