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CALMCandesartan And Lisinopril Microalbuminuria study. A study designed to assess and compare the efficacy of candesartan, lisinopril and their combination on blood pressure (BP) and albuminuria in hypertensive microalbuminuric diabetics.
Both systolic BP and diastolic BP were significantly reduced with candesartan or lisinopril, with no significant differences between them; both were more effective when combined than either alone, with a total reduction of SBP by 25.3 mm Hg and DBP by 16.3 mm Hg from baseline. The reduction in urinary albumin/creatinine ratio was 24% with candesartan, 39% with lisinopril and 50% with the combination.