calicheamicin


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calicheamicin

Any of a family of antitumour antibiotics derived from Micromonospora calichensis and Actinomadura verrucosospora, which have 4000-fold greater antitumoural activity than adriamycin, share a motif of double-triple-double carbon bonds (a so-called enediyene) and cleave DNA in a double-stranded fashion at specific DNA sequences.
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When Mylotarg binds to the CD33 antigen on the cell surface it is absorbed into the cell and calicheamicin is released causing cell death.
The product is an antibody-drug conjugate that includes cytotoxic agent calicheamicin.
Food and Drug Administration (FDA) on August 17, 2017, BESPONSA is an anti-CD22 antibody-drug conjugated to calicheamicin, a potent cytotoxic antibiotic.
Additionally, the mAb's long circulating half-life and low immunogenicity make it the ideal delivery system for powerful cytotoxic compounds such as monomethyl auristatin E (MMAE) and calicheamicin.
Thanks to this condensation calicheamicin is stable in physiologic buffers and is efficiently released inside lysosomes [20, 21].
According to the study, calicheamicin, a secondary metabolite of Micromonospora echinospora, is what gave the river its toxic reputation.
Mylotarg, a combination of gemtuzumab (IgG4k) conjugated with the cytotoxic antitumor antibiotic calicheamicin, is indicated for the treatment of patients with CD33-positive acute myeloid leukemia in first relapse who are 60 years of age or older.
Whitwam (Mississippi University for Women) who presented work he performed at the Sloan-Kettering Cancer Center on "Cloning and Characterizing the Calicheamicin Self-resi stance gene in Micromonospora echinospora.
Antibody-Targeted Chemotherapy with CMC-544: a CD22-Targeted Immunoconjugate of Calicheamicin for the Treatment of B-Lymphoid Malignancies.
By binding to the CD33 antigen on the cell surface, Mylotarg is absorbed into the cell and calicheamicin is released, causing death to the cancer cell.
CLONING AND CHARACTERIZING THE CALICHEAMICIN SELF-RESISTANCE GENE IN MICROMONOSPORA ECHINOSPORA
The oncofetal protein, 5T4, is a suitable target for antibody-guided anti-cancer chemotherapy with calicheamicin.