S100A6

(redirected from calcyclin)

S100A6

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression, differentiation and other intracellular activities. S100A6 is thought to play a role in stimulating Ca2+-dependent insulin release, stimulating prolactin secretion, and exocytosis.
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iTRAQ based quantitative proteomics approach validated the role of calcyclin binding protein (CacyBP) in promoting colorectal cancer metastasis.
In addition to development of structural-analysis methodologies, Case has contributed to the structure elucidation of many protein structures, including plastocyanin, thioredoxin, rusticyanin and calcyclin, and the electronic structures of active sites of metalloenzymes, iron-sulfur and heme proteins.
Additionally, some genes individually indicated an alteration of homeostasis or pathologic state; for example, fibroblast proliferation was potentially indicated by increased calcyclin (SA100a6) expression.