calcium sensitiser

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calcium sensitiser

Any of a new class of inotropic agents—e.g., levosimendan—that relax coronary smooth muscle and induce vasodilation by opening ATP-dependent K-channels in vascular smooth muscle. Calcium sensitisers may be useful in managing congestive heart failure.
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We found that the calcium sensitizer levosimendan improves the mechanical efficiency of the human diaphragm, suggesting a new, therapeutic approach to improve respiratory muscle function in patients with respiratory failure," said Leo Heunks, M.
Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction.
Electrophysiologic effects of a calcium sensitizer inotrope levosimendan administered intravenously in patients with normal cardiac function.
Levosimendan, a first-in-class calcium sensitizer, improves cardiac function and symptoms.
Initial data look promising for a calcium sensitizer called levosimendan, but results so far are mixed for a neurohormonal antagonist called tezosentan.
Levosimendan is a new calcium sensitizer and K-ATP channel opener, has emerged as an alternative option of pharmacologic inotropic support in patients with decompensated heart failure.
Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure.
In a series of studies presented at the meeting, the cardiac improvements seen during and after 24-hour intravenous infusions of the investigational calcium sensitizer were shown to be comparable to those achieved after a 48-hour infusion, Dr.
The calcium sensitizer levosimendan attenuates endotoxin evoked myocardial dysfunction in isolated guinea pig hearts.
physicians are cautious about the prospects of the calcium sensitizer levosimendan, citing disappointments with inotropic agents in the past, European physicians are far more positive, believing that the agent will directly address an important unmet need for safer inotropic drugs.
Levosimendan represents a new category of heart failure drugs, called calcium sensitizers, which enhance cardiac performance by potentiating the effects of calcium ions.
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