calcium sensitiser

calcium sensitiser

Any of a new class of inotropic agents—e.g., levosimendan—that relax coronary smooth muscle and induce vasodilation by opening ATP-dependent K-channels in vascular smooth muscle. Calcium sensitisers may be useful in managing congestive heart failure.
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Levosimendan is a calcium sensitiser that works through a unique triple mechanism of action.
According to the company, Levosimendan is a calcium sensitiser that works through a unique triple mechanism of action.
The calcium sensitiser levosimendan enhances the contractility of the myocardium and has vasodilating and anti-ischaemic properties.
Intensive care medicine is addressed by chapters on transoesophageal echocardiography, the new calcium sensitiser levosimendan, critical care outside the intensive care unit and critical care problems in biological disasters.
The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c.
The calcium sensitisers in particular are an attractive class of drug since their inotropic action is unique and not dependant on increased cAMP levels, or associated with increased energy expenditure.
Levosimendan is a myocardial calcium sensitiser and potassium ATP channel opener.
Levosimendan, a novel calcium sensitiser has been increasingly used in the last five years in various conditions in critically ill patients to improve myocardial contractility without increasing myocardial oxygen consumption.
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