calcium sensitiser

calcium sensitiser

Any of a new class of inotropic agents—e.g., levosimendan—that relax coronary smooth muscle and induce vasodilation by opening ATP-dependent K-channels in vascular smooth muscle. Calcium sensitisers may be useful in managing congestive heart failure.
References in periodicals archive ?
The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c.
A potential risk of calcium sensitisers is worsening of diastolic dysfunction by increasing the sensitivity of myofilaments to calcium during diastole.
Levosimendan is a myocardial calcium sensitiser and potassium ATP channel opener.
Levosimendan, a novel calcium sensitiser has been increasingly used in the last five years in various conditions in critically ill patients to improve myocardial contractility without increasing myocardial oxygen consumption.
Intensive care medicine is addressed by chapters on transoesophageal echocardiography, the new calcium sensitiser levosimendan, critical care outside the intensive care unit and critical care problems in biological disasters.
The calcium sensitiser levosimendan enhances the contractility of the myocardium and has vasodilating and anti-ischaemic properties.
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