CACNA1I

(redirected from calcium channel, voltage-dependent, alpha 1I subunit)

CACNA1I

A gene on chromosome 22q13.1 that encodes the alpha-1I subunit of a voltage-dependent calcium channel, which mediates the entry of calcium ions into excitable cells. These channels are also involved in various calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and apoptosis. CACNA1I gives rise to T-type calcium channels that belong to the low-voltage activated (LVA) group, which are remarkable for opening at very negative potentials and for voltage-dependent inactivation. T-type channels are pacemakers for both central neurons and cardiac nodal cells, and support calcium signalling in secretory cells and vascular smooth muscle. They may be involved in modulating firing patterns of neurons, which is key to information processing as well as cell growth.
References in classic literature ?
So he said to him, "It seems to me, Senor Knight-errant, that your worship has made choice of one of the most austere professions in the world, and I imagine even that of the Carthusian monks is not so austere.
Behind these palaces, extended in all directions, now broken, fenced in, battlemented like a citadel, now veiled by great trees like a Carthusian convent, the immense and multiform enclosure of that miraculous Hôtel de Saint-Pol, where the King of France possessed the means of lodging superbly two and twenty princes of the rank of the dauphin and the Duke of Burgundy, with their domestics and their suites, without counting the great lords, and the emperor when he came to view Paris, and the lions, who had their separate Hôtel at the royal Hôtel.
The Carthusians were in the chapel, I went thither to join in their prayers, and there my resolutions vanished.
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