calcitriol


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calcitriol

 [kal´sĭ-tri´ol]
1,25-dihydroxycholecalciferol; a form of vitamin D used as a calcium regulator in the management of hypocalcemia in conditions such as rickets, osteodystrophy, hypoparathyroidism, and complications of renal dialysis; administered orally or intravenously.

cal·ci·tri·ol

(kal'si-trī'ol),
1α,25-Dihydroxycholecalciferol (thus, a 1,3,25-triol); formation of calcitriol is the second step in the biologic conversion of vitamin D3 to its active form; it is more potent than calcidiol.

calcitriol

/cal·ci·tri·ol/ (kal″sĭ-tri´ol)
2. a preparation of this compound, used in the treatment of hypocalcemia, hypophosphatemia, rickets, and osteodystrophy associated with a variety of disorders.

calcitriol

[kalsit′rē·ôl]
the active form of vitamin D, a regulator of calcium metabolism.
indication It is prescribed in the management of hypocalcemia in patients undergoing chronic renal dialysis and in patients with hypoparathyroidism.
contraindications Hypercalcemia, evidence of vitamin D toxicity, malabsorption syndrome, decreased renal function, or known sensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are renal toxicity and those associated with hypercalcemia, such as soft tissue calcification.

calcitriol

A form of vitamin D3 which promotes intestinal absorption of Ca2+, increases renal tubular reabsorption of Ca2+ and reduces Ca2+ resorption by bone.
 
Indications
Postmenopausal and corticosteroid-induced osteoporosis, hypocalcaemia, hypoparathyroidism, osteomalacia, rickets, renal osteodystrophy, chronic renal dialysis.

Adverse effects
Nausea, vomiting, constipation, anorexia, headache, thirst, sweating, polyuria—all due to hypercalcaemia.

calcitriol

A vitamin D analogue drug used in the treatment of low calcium levels resulting from kidney disease. Brand names are Calcijex, Rocatrol and Silkis.

calcitriol

vitamin D derivative used to treat vitamin D deficiency, postmenopausal osteoporosis and rickets

calcitriol (kal´sitri´ol),

n brand name: Calcijex;
drug class: vitamin D3 hormone;
action: increases intestinal absorption of calcium and phosphorus;
uses: hypocalcemia in chronic renal dialysis and rickets, nutritional supplement.

calcitriol

a nonproprietary name for 1,25-dihydroxycholecalciferol; used as a calcium regulator in the management of hypocalcemia.
References in periodicals archive ?
In the evolution of CKD, FGF-23 concentrations increase with reduced renal function long before calcitriol concentrations decline or PTH rises (19).
It was discovered that calcitriol activates the transcription of tryptophan hydroxylase 2, a gene that converts the amino acid tryptophan to serotonin in the brain.
He refers to calcitriol as a "potent steroid hormone," not to be confused with anabolic steroid hormones that are banned from athletic competition by the World Anti-Doping Agency (2).
First, Hayes' team compared the effectiveness of a single dose of calcitriol to that of a comparable dose of a glucocorticoid, a drug now administered to MS patients who experience a bad neurological episode.
Valorar y educar en relacion a la ingesta de alimentos ricos en fosforo y la importancia de la correcta administracion de la terapia medicamentosa (quelantes del fosforo, analogos de vitamina D, calcitriol oral).
and its operating infrastructure is a ready-made sales and distribution channel that is able to provide seamless integration into the commercial market for its drug products, Calcitriol and SFP upon FDA market approval.
The interaction of calcitriol with vitamin D receptors increases the efficiency of intestinal calcium absorption from only 10% or 15% to 30% or 40% and phosphorus absorption from about 60% to approximately 80%.
10) Calcitriol is the most active form of vitamin D.
Surgical resection of the colon can impair absorption and in the elderly, absorption diminishes because of the reduced response to calcitriol (2).
Novacea has the exclusive worldwide rights to OHSU's technology for high-dose pulse administration of calcitriol and its analogs.
Exercise-trained young men have higher calcium absorption rates and plasma calcitriol levels compared with age-matched sedentary controls.
However, there was interestingly, an increase in calcitriol levels seen in all human subjects following berberine treatment (mean 59.

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