CALCRL

(redirected from calcitonin receptor-like)

CALCRL

A gene on chromosome 2q32.1 that encodes a G protein-coupled receptor, which with RAMP1 acts as a receptor for calcitonin-gene-related peptide; with RAMP2 acts as a receptor for adrenomedullin-1; and with RAMP3 acts as a receptor for adrenomedullin-2.
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The association of another G protein-coupled receptors (GPCRs), the calcitonin receptor-like receptor (CLR), and RAMP1 generates the [[alpha]-CGRP.
Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?
Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.

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