calcilytic

calcilytic

Of any drug that decreases activation of CALCIUM-SENSING RECEPTORS. Calcilytics increase secretion of parathyroid hormone and can promote its anabolic effects in OSTEOPOROSIS. Compare CALCIMIMETIC.
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NPS's earlier stage pipeline includes two calcilytic compounds, NPSP790 and NPSP795, with potential application in rare disorders involving increased calcium receptor activity, such as autosomal dominant hypocalcemia with hypercalciuria (ADHH).
Calcilytic drugs act as antagonists of calcium-sensing receptors leading to hypocalcemia, thus stimulating pulsatile release of PTH from parathyroid cells.
Wnt signaling inhibitors and calcilytic drugs are promising new anabolic agents
Therefore, it is plausible that intermittent administration of a calcilytic could mirror this cyclical pattern in endogenous PTH, promoting anabolic over catabolic actions.
The clinical development and manufacturing planning processes are underway for the clinical proof-of-concept study of the company's calcilytic compounds, NPSP790 and NPSP795.
A failed treatment for osteoporosis, a family of drugs called calcilytics, seem to be showing huge promise in reversing the asthma allergic reaction.
One of the researchers, Professor Daniela Riccardi, from Cardiff University School of Biosciences, has said 'If we can prove that calcilytics are safe when administered directly to the lung in people, then in five years we could be in a position to treat patients and potentially stop asthma from happening in the first place.
They claim a class of drug known as calcilytics can manipulate CaSR and reverse all asthma symptoms.
Researchers pumped osteoporosis drugs called calcilytics into the lungs to deactivate the gene and reversed inflammation.
on a treatment for hyperparathyroidism (HPT); its calcilytics (for osteoporosis) program with with SmithKline Beecham PLC; its work on excitatory amino acid receptor antagonists with Eli Lilly and Co.
They claim a class of drugs known as calcilytics can manipulate CaSR and reverse all asthma symptoms.
Using calcilytics, nebulized directly into the lungs, we show it's possible to deactivate CaSR and prevent symptoms.