calcification


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to calcification: dystrophic calcification

calcification

 [kal″sĭ-fĭ-ka´shun]
the deposit of calcium salts, mostly calcium phosphate, in body tissues. The normal absorption of calcium is facilitated by parathyroid hormone and by vitamin D. When there are increased amounts of parathyroid hormone in the blood (as in hyperparathyroidism), there is deposition of calcium in the alveoli of the lungs, the renal tubules, the thyroid gland, the gastric mucosa, and the arterial walls. Normally calcium is deposited in the bone matrix to insure stability and strength of the bone and in growing teeth.
dystrophic calcification the deposition of calcium in abnormal tissue, such as scar tissue or atherosclerotic plaques, without abnormalities of blood calcium.
eggshell calcification deposition of a thin layer of calcium around a thoracic lymph node, often seen in silicosis.

cal·ci·fi·ca·tion

(kal'si-fi-kā'shŭn),
1. Deposition of lime or other insoluble calcium salts.
2. A process in which tissue or noncellular material in the body becomes hardened as the result of precipitates or larger deposits of insoluble salts of calcium (and also magnesium), especially calcium carbonate and phosphate (hydroxyapatite) normally occurring only in the formation of bone and teeth.
3. A dense opacity (less dense than metal, however) on a radiographic image.
[L. calx, lime, + facio, to make]

calcification

/cal·ci·fi·ca·tion/ (kal″sĭ-fĭ-ka´shun) the deposit of calcium salts in a tissue.
dystrophic calcification  the deposition of calcium in abnormal tissue, such as scar tissue or atherosclerotic plaques, without abnormalities of blood calcium.
eggshell calcification  deposition of a thin layer of calcium around a thoracic lymph node, often seen in silicosis.
Mönckeberg's calcification  see under arteriosclerosis.

calcification

(kăl′sə-fĭ-kā′shən)
n.
1.
a. Impregnation with calcium or calcium salts, as with calcium carbonate.
b. Hardening, as of tissue, by such impregnation.
2. A calcified substance or part.

calcification

Etymology: L, calx + facere, to make
the accumulation of calcium salts in tissues. Normally, about 99% of all the calcium entering the human body is deposited in the bones and teeth; the remaining 1% is dissolved in body fluids such as blood. Disorders affecting the delicate balance between calcium and other minerals, parathyroid hormone, and vitamin D can result in calcium deposits in arteries, kidneys, lung alveoli, and other tissues, interfering with normal organ function. See also calcitonin, calcium, calculus. calcific, adj.

calcification

The deposition of calcium in tissues; the term mineralisation is often used for physiologic calcification.

calcification

Medtalk The deposition of calcium in tissues

cal·ci·fi·ca·tion

(kal'si-fi-kā'shŭn)
1. Deposition of lime or other insoluble calcium salts.
2. A process in which tissue or noncellular material in the body becomes hardened as the result of precipitates or larger deposits of insoluble salts of calcium (and also magnesium), especially calcium carbonate and phosphate (hydroxyapatite), normally occurring only in the formation of bone and teeth.
Synonym(s): calcareous infiltration.
[L. calx, lime, + facio, to make]

calcification

Deposition of calcium salts, usually calcium hydroxyapatite crystals, in body tissues, especially when there has been prolonged inflammation or injury. Calcification is normal in bones and teeth.

cal·ci·fi·ca·tion

(kal'si-fi-kā'shŭn)
1. Deposition of lime or other insoluble calcium salts.
2. Process in which tissue or noncellular material in the body hardens due to precipitates or larger deposits of insoluble salts of calcium, especially calcium carbonate and phosphate normally occurring only in the formation of bone and teeth.
[L. calx, lime, + facio, to make]

calcification (kal´sifikā´shən),

n the process whereby calcium salts are deposited in an organic matrix. The condition may be normal, as in bone and tooth formation, or pathologic.
n the pathologic deposition of calcium salts in necrotic or degenerated tissues.
calcification, ectopic oral,
n the displaced accumulation of hardened calcium salts in the oral cavity; stones found in pulp or saliva. See also salivary stone and denticle.
calcification, metastatic,
n the pathologic deposition of calcium salts in previously undamaged tissues. This process is caused by an excessively high level of blood calcium, such as in the hyperparathyroid.

calcification

the deposit of calcium salts in a tissue. The normal absorption of calcium is facilitated by parathyroid hormone and by vitamin D. In poisoning with calcinogenic glycosides and when there are increased amounts of parathyroid hormone in the blood (as in hyperparathyroidism), there is deposition of calcium in the soft tissue. (In hyperparathyroidism secondary to renal disease there is deposition in the alveoli of the lungs, the renal tubules, beneath the parietal pleura, the gastric mucosa, and the arterial walls.) Normally calcium is deposited in the bone matrix to insure stability and strength of the bone. In osteomalacia there is an excess of unmineralized osteoid because the aged well-mineralized bone is replaced by a matrix that is inadequately mineralized.

dystrophic calcification
the deposition of calcium in abnormal tissue without abnormalities of blood calcium.
metastatic calcification
deposition of calcium in tissues as a result of abnormalities of calcium and phosphorus levels in the blood and tissue fluids.
nutritional calcification
calcification in soft tissues as a result of an increased intake of calcium.
soft tissue calcification
see metastatic calcification (above), dystrophic calcification (above).

Patient discussion about calcification

Q. Please let me know what is breast calcification? My mom aged 52 years is diagnosed with breast cancer and is suffering for the past 5 years. I am scared too as I know that possibility of breast cancer is also linked genetically. The mammogram report shows some white spots on mammogram. But it has been recorded as breast calcifications. Doctor advised me not to worry as this has got no relevance to breast cancer. Please let me know what is breast calcification?

A. These are tiny calcium deposits in the breast tissue. You can not touch or feel breast calcifications. To know about them the only way is by mammogram. They are usually not cancerous but in some forms like tight clusters with irregular shapes can indicate breast cancer. There are two main types: microcalfications and macrocalfications. But if your doctor says that they pose no threat then I am sure you have nothing to worry about. Just follow his advices.

More discussions about calcification
References in periodicals archive ?
Nanobacteria: An alternative mechanism for pathogenic intro- and extra-cellular calcification and stone formation.
Matrix Gla -protein: The calcification inhibitor in need of vitamin K.
According to the research, Klotho lessens vascular calcification by enhancing the urine's phosphate excretions (essential for building and repairing bones and teeth, helping nerve function and making muscles contract, but it can be toxic when levels are high); and preserving kidney fluid filtration.
17) Serum undercarboxylated MGP is decreased in patients at risk of cardiovascular calcification due to deposition of undercarboxylated MGP in areas of vascular calcification.
Among women aged 65 or older, bisphosphonate use was associated with a significantly lower prevalence of cardiovascular calcification at nearly all anatomic sites assessed.
Amyloid angiopathy results in gyriform calcification and sclerotic changes in the medullary arteries.
There were no significant differences in the correlation rates of the following: whether surgeons or radiologists performed the biopsy, whether cores with calcifications were identified in any way, and whether radiologic reports and images were reviewed before verification of pathology reports.
Taking steps to protect against calcification and thickening of the aortic valve would be expected to significantly reduce stenosis risk in one's older years, when surgical procedures are of particular risk.
Metastatic calcification is caused by a disturbance in calcium metabolism.
Acidification has a considerable effect on calcification in shellfish (Gazeau et al.
It was found that women were more likely to develop calcification in their heart arteries if they lived in deprived environments compared to women who lived in more well-to-do and cohesive neighbourhoods, BBC radio reported.