The compounds kahweol and cafestol
enhance glutathione S-transferase action.
Kahweol and cafestol
increase metabolic activity of GST of many different classes (alpha, mu, pi, and theta) and in several organs in the rat (Huber et al.
The diterpenes, cafestol
and kahweol are the substances in coffee responsible (8) and boiled, Turkish/Greek and cafetiere coffee contain the highest levels of diterpene.
The coffee components kahweol and cafestol
induce gammaglutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat.
In addition, SVETOL does not contain two compounds called cafestol
and kahweol that are typically found in most versions of GCBE; they have been shown to cause negative side effects in some people.
Two substances in coffee -- kahweol and cafestol
-- raise cholesterol levels.
His team went on to identify a compound found in both decaf and normal coffee called cafestol
that seems partially responsible for its neuro-protective effects.
, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation.
Coffee made other ways, including French press and espresso, has higher levels of cafestol
In cell cultures and animal studies, two diterpenes called cafestol
and kahweol inhibit certain carcinogens and reduce concentrations of liver DNA adducts (pieces of DNA bound to cancer-causing chemicals).
24) Coffee contains two terpenes, cafestol
and kahweol, that are responsible for the elevated cholesterol.
That's because filters remove most of the cafestol