cafe-au-lait spots


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ca·fé-au-lait spots

(ka-fā'ō-lā' spots)
Pigmented cutaneous lesions, ranging from light to dark brown; due to excess of melanosomes in the malpighian cells, rather than to an excess of melanocytes; major cutaneous manifestation of neurofibromatosis (von Recklinghausen disease).

café-au-lait spots,

n.pl See spots, café-au-lait.
References in periodicals archive ?
The bony lesions, involved gonads, and cafe-au-lait spots are typically all on the same side of the body.
Cafe-au-lait spots are from overproduction of the enzyme tyrosinase, which is the rate-limiting step in melanin production.
On physical examination, there were multiple cafe-au-lait spots and presence of axillary freckles.
5, 6) The classic clinical characteristics of NF1 include cafe-au-lait spots, neurofibroma and several bony anomalies.
Common abnormalities were growth retardation, cafe-au-lait spots, hyperpigmentation, microcephaly, finger and thumb deformities Figure 1), Sprengel deformity, and hypogenitalism.
RAG 11 / M growth retardation 8 -- cafe-au-lait spots radial ray defects (thumbs) pallor bruising and epistaxis hepatomegaly (5cm) splenomegaly (8cm) cafe-au-lait spots growth retardation microcephaly 2.
Cutaneous and plexiform fibromas, cafe-au-lait spots, and optic gliomas are common findings in this hereditary condition.
The most common are cafe-au-lait spots - coffee-coloured marks found anywhere on the body - moles and bluish-grey Mongolian spots.
Some authors have reported an association of juvenile xanthogranuloma with cafe-au-lait spots and a family history of neurofibromatosis type 1 or type 2.
Neurofibromatosis Type 1 (NF1) is a genetic disorder affecting about 1 in 3,500 people worldwide and characterized by multiple cafe-au-lait spots and neurofibromas on or under the skin.