CDH2

(redirected from cadherin-2)

CDH2

A gene on chromosome 18q11.2 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH2 functions during gastrulation and is required for establishing left-right asymmetry. At certain CNS synapses, presynaptic to postsynaptic adhesion is mediated in part by CDH2; in the hippocampus, it may regulate dendritic spine density.
Mentioned in ?
References in periodicals archive ?
If activity works through Cadherin-2 to guide cells, it would present a novel way of transmitting information from outside to the inside of cells.
Through collaboration between Harvard University, the Cummings School of Veterinary Medicine at Tufts, the University of Massachusetts Medical School and others, scientists discovered that the canine chromosome 7 location within the neural cadherin-2 gene, or CDH2, confers a high risk of susceptibility to the disorder.
The chromosome 7 location most significantly associated with CCD is located within the neural cadherin-2 gene, CDH2.