CDH3

(redirected from cadherin 3, type 1, P-cadherin)

CDH3

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH3 is also a retired HUGO symbol for what is now designated CDH15, see there.

Molecular pathology
Loss of heterozygosity mutations of CDH3 occur in breast and prostate cancer; aberrant expression of cadherin 3 occurs in cervical adenocarcinomas. CDH3 mutation causes congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia with ectrodactyly and macular dystrophy.