cadherin


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cad·her·in

(kad-hēr'-in),
One of a class of integral-membrane glycoproteins that has a role in cell-cell adhesion and is important in morphogenesis and differentiation; E-cadherin is also known as uvomorulin and is concentrated in the belt desmosome in epithelial cells; N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates; P-cadherin is expressed in placental and epidermal cells. All are calcium-binding proteins.
[cell + adhere + -in]

cadherin

(kăd-hîr′ĭn)
n.
Any of a group of proteins that span the plasma membrane of eukaryotic cells and, in the presence of calcium, bind to identical proteins in adjacent cells, thus linking cells together in tissues.

cad·her·in

(kad-hēr'in)
One of a class of integral-membrane glycoproteins that has a role in cell-to-cell adhesion and is important in morphogenesis and differentiation; E-cadherin (also known as uvomorulin) is concentrated in the belt desmosome in epithelial cells; N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates; P-cadherin is expressed in placental and epidermal cells.

cadherin

one of a family of GLYCOPROTEINS that are involved in cell to cell attachment for preserving the integrity of all solid tissues. Cadherins have three major regions: the extracellular region that mediates ADHESION (cadherin to cadherin) for cell to cell binding; the transmembrane region; and the cytoplasmic region that extends into the cell and interacts with CATENINS, which in turn are linked to the ACTIN of the CYTOSKELETON. Loss of cadherin binding correlates with the invasion of CANCER.

Cadherins also effect tissue formation by modifying their binding strength to allow cell sorting and migration.

References in periodicals archive ?
The interface statistics of each protein including all mutants and Cry2Ac11 were analyzed for all three receptors including Helicoverpa armigera APN and Cadherin and Aedes aegypti ALP one by one.
B) The cells were immunostained with anti-E- cadherin, anti-N-cadherin and anti-Fibronectin antibodies, and nuclei were counterstained with DAPI.
Adhesive and signaling functions of cadherins and catenins in vertebrate development.
Andrews JL, Kim AC, Hens JR: The role and function of cadherins in the mammary gland.
Compared with epithelial cells, this change causes a reduction in mesenchymal cell polarization, inducing the cells to acquire motility properties through mechanisms that are not completely understood, and allows the cadherin switch to associate with the invasive phenotype of cells transformed by the EMT (61).
This early adhesion is largely based on transmembrane molecules of the cadherin superfamily, and it results in the formation of a monolayer embryo.
The researchers now conclude that when these snippets bind to a protein called cadherin, they lose a molecular fragment.
Takeichi discovered that cadherin molecules are involved in the adhesion of cells and metastasis of cancers, organizers said.
Elevated concentration of soluble vascular endothelial cadherin is associated with coronary atherosclerosis.