cadherin


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cad·her·in

(kad-hēr'-in),
One of a class of integral-membrane glycoproteins that has a role in cell-cell adhesion and is important in morphogenesis and differentiation; E-cadherin is also known as uvomorulin and is concentrated in the belt desmosome in epithelial cells; N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates; P-cadherin is expressed in placental and epidermal cells. All are calcium-binding proteins.
[cell + adhere + -in]

cadherin

(kăd-hîr′ĭn)
n.
Any of a group of proteins that span the plasma membrane of eukaryotic cells and, in the presence of calcium, bind to identical proteins in adjacent cells, thus linking cells together in tissues.

cad·her·in

(kad-hēr'in)
One of a class of integral-membrane glycoproteins that has a role in cell-to-cell adhesion and is important in morphogenesis and differentiation; E-cadherin (also known as uvomorulin) is concentrated in the belt desmosome in epithelial cells; N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates; P-cadherin is expressed in placental and epidermal cells.

cadherin

one of a family of GLYCOPROTEINS that are involved in cell to cell attachment for preserving the integrity of all solid tissues. Cadherins have three major regions: the extracellular region that mediates ADHESION (cadherin to cadherin) for cell to cell binding; the transmembrane region; and the cytoplasmic region that extends into the cell and interacts with CATENINS, which in turn are linked to the ACTIN of the CYTOSKELETON. Loss of cadherin binding correlates with the invasion of CANCER.

Cadherins also effect tissue formation by modifying their binding strength to allow cell sorting and migration.

References in periodicals archive ?
One such circumstance in which cadherin 3 and matrix metalloproteinase 10 might prove useful is in patients with melanoma in situ with extensive regression.
Tabashnik knew from lab experiments that pink bollworms evolve resistance by developing a balky version of cadherin, which doesn't bind well with the Cry1A pieces.
For example, the RCC marker antigen and CD10 are preferentially expressed in proximal tubules and the corresponding clear cell RCC; S100A, claudins, and kidney-specific cadherin are preferentially expressed in distal convoluted tubules and corresponding chromophobe RCC and oncocytoma.
In contrast, the HK-2 (blank vector) cells had significantly elevated expression of N- and K- cadherin compared to that of HPT and HK-2 MT-3 cell lines.
Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues.
The team's preliminary investigations suggest that the chemical that sends tumor cells on their way is a protein called cadherin, which is secreted by healthy cells.
E-cadherin, one subtype of Cadherins family, is the adhesion molecule found in mammalian cells which is an important factor in cell-cell adhesion.
The bacteria use a molecule called cadherin, which bridges these junctions, to move from cell to cell, Sansonetti reported in the March 11,1994 Cell.
PAX-2 is a helpful marker for diagnosing metastatic renal cell carcinoma: comparison with the renal cell carcinoma marker antigen and kidney-specific cadherin.
Several immunohistochemical markers are known to help in the diagnosis of renal neoplasms, among which are the renal cell carcinoma marker antigen (RCCM), kidney-specific cadherin (KSC), and PAX-2.