cachexia


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

cachexia

 [kah-kek´se-ah]
a profound and marked state of constitutional disorder; general ill health and malnutrition. adj. adj cachec´tic.
cachexia hypophysiopri´va symptoms resulting from total loss of pituitary function, including loss of sexual function, bradycardia, hypothermia, apathy, and coma.
malarial cachexia the physical signs resulting from antecedent attacks of severe malaria, including anemia, sallow skin, yellow sclera, splenomegaly, hepatomegaly, and, in children, retardation of growth and puberty.
pituitary cachexia simmonds' disease.

ca·chex·i·a

(kă-kek'sē-ă),
A general weight loss and wasting occurring in the course of a chronic disease or emotional disturbance.
[G. kakos, bad, + hexis, condition of body]

cachexia

/ca·chex·ia/ (kah-kek´se-ah) a profound and marked state of constitutional disorder; general ill health and malnutrition.cachec´tic
cachexia hypophysiopri´va  the train of symptoms resulting from total deprivation of pituitary function, including loss of sexual function, bradycardia, hypothermia, and coma.
malarial cachexia  the physical signs resulting from antecedent attacks of severe malaria, including anemia, sallow skin, yellow sclera, splenomegaly, hepatomegaly, and, in children, retardation of growth and puberty.
pituitary cachexia  see panhypopituitarism.

cachexia

(kə-kĕk′sē-ə)
n.
Weight loss, wasting of muscle, loss of appetite, and general debility that can occur during a chronic disease.

cachexia

[kəkek′sē·ə]
Etymology: Gk, kakos, bad, hexis, state
general ill health and malnutrition, marked by weakness and emaciation, usually associated with severe disease, such as tuberculosis or cancer. Also called cachexy. cachectic, adj.
enlarge picture
Cachexia

cachexia

A state of severe weight loss and tissue wasting seconday to underlying disease—e.g., AIDS, terminal cancer, congestive heart failure, COPD, multiple sclerosis, anorexia nervosa, malnutrition, congestive heart failure, tuberculosis, familial amyloid polyneuropathy, mercury poisoning and hormone deficiency.

Clinical findings
Weight loss, muscle atrophy, fatigue, weakness and anorexia.
 
Mechanism
Cachexia is attributed to an interplay of TNF-alpha, interferon gamma and interleukin 6, and proteolysis-inducing factor, which is secreted by cancers.

Management
Corticosteroids, progesterone-like agents, selective adrenergic receptor modulators.

cachexia

Clinical medicine A state of severe weight lose and tissue wasting 2º to underlying disease–eg, AIDS, terminal CA, anorexia nervosa, or malnutrition. See Tumor necrosis factor.

ca·chex·i·a

(kă-kek'sē-ă)
A general weight loss and wasting occurring in the course of a chronic disease or emotional disturbance.
[G. kakos, bad, + hexis, condition of body]

cachexia

A state of severe muscle wasting and weakness occurring in the late stages of serious illnesses such as cancer. The usual condition of bodily decline in those dying after long debilitating illnesses. Cachexia is not due to malnutrition and research findings suggest that an important element in the causation may be selective depletion of the myosin heavy chain in myofibrillary proteins.

Cachexia

A condition of general ill health, malnutrition, undesired weight loss, and physical weakness, often associated with cancer.

cachexia (k·kekˑ·sē·),

n state of health with physical atrophy and weakness often found in the last stages of terminal illness.
Enlarge picture
Cachexia.

ca·chex·i·a

(kă-kek'sē-ă)
General weight loss and wasting in the course of a chronic disease or emotional disturbance.
[G. kakos, bad, + hexis, condition of body]

cachexia (kəkek´sēə),

n the weakness, loss of weight, atrophy, and emaciation caused by severe or chronic disease such as with AIDS.
cachexia, hypophysial,
cachexia hypopituitary,

cachexia

a profound and marked state of constitutional disorder; general ill health and malnutrition. See also emaciation.

cardiac cachexia
severe wasting that occurs in association with chronic cardiac insufficiency. The result of anorexia, malabsorption and poor tissue perfusion with cellular anoxia.
pituitary cachexia
that due to diminution or absence of pituitary function. Manifested by progressive loss of body weight associated with muscle atrophy due to lack of protein anabolism in the absence of growth hormone.
References in periodicals archive ?
Cancer cachexia is the severe and progressive loss of muscle that occurs in cancer patients and is responsible for at least 20 percent of cancer deaths.
Since ghrelin agonists such as AEZS-130 have been shown to stimulate food intake and increase body weight in rats and mice, AEZS-130 could lead to better quality of life for patients with cancer-induced cachexia.
Historically, treatment has focused on the underlying illnesses that predispose patients to cachexia, and it is only very recently that cachexia has been regarded as a treatable syndrome in its own right.
Kumar and colleagues suggest that eicosapentaenoic acid (EPA) might be helpful in preventing and treating cancer cachexia.
In addition, all patients had at least two causes of secondary cachexia, with a median of four causes.
Riccardo Braglia, Chief Executive Officer of Helsinn Group commented, "With this EMA submission, we are one step closer to bringing this new and potentially effective treatment to market, meaning that the quality of life for patients with non-small cell lung cancer who suffer from anorexia, cachexia, could soon improve.
Physical examination showed moderate cachexia and low-grade fever (38.
Research by Pariza's team now suggests that CLA may also prove beneficial in treating cachexia, a wasting that occurs when the body catabolizes -- burns up -- muscle in an attempt to meet the high energy demands of fighting certain chronic diseases, such as malaria or cancer.
com/research/56xndl/cancer_cachexia) has announced the addition of GlobalData's new report "Cancer Cachexia Global Clinical Trials Review, H1, 2013" to their offering.