KAT5

(redirected from cPLA2)
Also found in: Acronyms.

KAT5

A gene on chromosome 11q13 that encodes a catalytic subunit of the NuA4 histone acetyltransferase complex (NuA4 HAC) involved in transcriptional activation of genes, principally by acetylating nucleosomal histones H4 and H2A. The NuA4 HAC may be required for activating transcription programmes of oncogene and proto-oncogene mediated growth induction, tumour suppressor-mediated growth arrest/replicative senescence, apoptosis, and DNA repair. Post-translational modifications include sumoylation, phosphorylation, ubiquination and autoacetylation.
References in periodicals archive ?
To our knowledge, only 1 other study has reported on this subject to date (25); but the authors of that study claimed that the PLA2 activity identified in their study was most likely from cPLA2 and iPLA2 types.
BL-3030 is aimed at inhibiting the formation of cPLA2 - an enzyme that plays a major role in a number of inflammatory diseases including rheumatoid arthritis (RA), asthma, and adult respiratory distress syndrome (ARDS).