BIRC3

(redirected from cIAP2)
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BIRC3

A gene on chromosome 11q22 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. BIRC3 acts by binding to tumour necrosis factor receptor-associated factors TRAF1 and TRAF2, interfering with activation of ICE-like proteases.
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They found that cIAP2, which functions by modifying and activating survival factors in the cell, steers the body away from an inflammatory and auto-destructive process known as necrotic death.
cIAP2 therefore not only protects the infected cells from dying in such a manner, but also protects uninfected neighboring cells in the same tissue.
302) However, although apoptosis-inducing genes such as TNF-[alpha] and TNF-related apoptosis-inducing ligand are highly expressed, the cells are likely protected from apoptosis due to expression of the caspase-8 antagonist cFLIP (cellular FLICE inhibitory protein), the caspase inhibitor cIAP2, and the antioxidant enzyme manganese superoxide dismutase.