BIRC2

(redirected from cIAP1)
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BIRC2

A gene on chromosome 11q22 that encodes a protein which inhibits apoptosis by binding to tumour necrosis factor-receptor-associated factors TRAF1 and TRAF2, interfering with activation of ICE-like proteases.
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Similar to Smac/DIABLO, HtrA2/Omi binds to and neutralizes IAPs (XIAP, cIAP1, and cIAP2) via its N-terminal IAP-binding motif, therefore releasing the inhibition of IAP to caspase-3, -7, and -9.
2007), mientras que las proteinas Smac/Diablo y HtrA2/Om promueven apoptosis por inhibicion de IAP (inhibidores de proteinas apoptoticas) como cIAP1, cIAP2 y XIAP (Elmore, 2007; Huerta et al.
Como ya mencionamos, Smac/DIABLO, puede liberar a las procaspasas de la influencia inhibidora de las IAP, como XIAP (proteina inhibidora de apoptosis ligada al X), CIAP1 (proteina inhibidora de apoptosis celular 1), CIAP2 (proteina inhibidora de apoptosis celular 2) y NIAP (proteina inhibidora de apoptosis neuronal), para que sean activadas por auto catalisis.