PRKAR1A(redirected from cAMP-dependent protein kinase type-I-alpha regulatory chain)
PRKAR1AA gene on chromosome 17q23-q24 that encodes one of the regulatory subunits that comprise cAMP-dependent protein kinase. This enzyme transduces activating signals by phosphorylating different target proteins. PRKAR1A downregulates expression of liver genes in hepatoma/fibroblast hybrids.
PRKAR1A mutations cause Carney complex; it can fuse to the RET proto-oncogene by gene rearrangement and form PTC2, a thyroid tumour-specific chimeric oncogene.