cAMP-dependent protein kinase


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cAMP-dependent protein kinase

a tetrameric protein composed of two regulatory subunits that bind cAMP, and two catalytic subunits that catalyze the transfer of a phosphoryl group from ATP to a target enzyme.
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Almost 60% of patients with known Carney complex have an inactivating mutation in the PRKAR1A gene, which codes for the regulatory subunit type 1a of the cAMP-dependent protein kinase A, located on chromosome 17q23-24 (4), leading to aberrant function of protein kinase A and increased phosphorylation of targets concerned with cell transcription, metabolism, cell cycle progression, and apoptosis (5).
For example, catecholamine rapidly activates the [beta]-adrenergic receptor and the cAMP-dependent protein kinase A (PKA) axis (McKnight et al.
We examined Boa's ability to activate different downstream signaling transduction pathways (kinases) by retreating GC-1 cells with the PKG inhibitor KT5823, the ERK inhibitor PD98059, the G[alpha]i/G[alpha]q inhibitor peruses toxin (PTX), the Src inhibitor PP2, the EGFR inhibitor AG-1478, the cAMP-dependent protein kinase (PKA) inhibitor H89, and the G[alpha]s inhibitor NF449 before 12-hr exposure to 10(-9) M BPA, a concentration that provided maximum cell proliferation and then evaluated cell viability using the MTT assay.
In this study we established cooperative interaction between substrate binding sites of the cAMP-dependent protein kinase catalytic subunit (protein kinase A, EC 2.
The CAMP-dependent protein kinase substrate Rapt in platelets from patients with obsessive compulsive disorder or schizophrenia.
The enzyme was expressed in Escherichia coli [9] and thereafter stoichiometrically phosphorylated by the catalytic subunit of cAMP-dependent protein kinase [10].
9:50 BREAK 10:10 "Phosphorylation of the type I regulatory subunit of cAMP-dependent protein kinase in rat tissues.
But the trio acted synergistically to upregulate a regulatory subunit of cAMP-dependent protein kinase, a ubiquitous protein involved in neurologic pathways and a key regulator of neuronal growth in the clam embryo model.

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