c-src

c-src

a tyrosine kinase that participates in signal transduction pathways that regulate growth of cells. It hybridizes with oncogenes of the highly virulent Rous sarcoma virus. The human c-src gene is located at 20g12-13 on the long arm of chromosome 20.
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In addition, c-Src inhibition can recover cardiac [Na.
Protooncogene tyrosine-protein kinase SRC, also known as protooncogene c-Src or simply c-Src, is a nonreceptor tyrosine kinase protein that in humans is encoded by the SRC gene.
Hence, we used the c-Src inhibitor PP2 to evaluate the involvement of c-Src in gene transcription stimulated by atrazine and E2 in BG-1 cells (see Supplemental Material, Table S3) and 2008 cells (data not shown).
Mda-9/syntenin was originally cloned in Fisher's laboratory, and was shown in previous studies to interact with another protein, c-Src, to start a series of chemical reactions that lead to increased metastasis.
Through mechanisms other than antioxidant function: The non-antioxidant mechanism occurs via two key molecular checkpoints: c-Src and 12-lipoxygenase.
N-ACETYL CYSTEINE FOSTERS INACTIVATION AND TRANSFER TO ENDOLYSOSOMES OF C-SRC.
Chandan Sen and his group of researchers at The Ohio State University Medical Center showed extremely low level of Tocomin natural full spectrum palm tocotrienol complex prevented glutamate-induced death of neuron cells in mice through the inhibition of c-Src kinase and 12-lipoxygenase.
The targets included focal adhesion kinase (FAK), Pyk2 (a soluble form of FAK), c-Src which can phosphorylate FAK, and the MAP kinases ERK1/2, p38 and JNK.
An autophosphorylatable band comigrating with c-Src is present in the anti-PECAM-1 immunoprecipitate, and c-Src phosphorylates and binds to a GST fusion protein containing the PECAM-1 cytoplasmic domain.
Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNF alpha secretion in macrophages.