c-src

c-src

a tyrosine kinase that participates in signal transduction pathways that regulate growth of cells. It hybridizes with oncogenes of the highly virulent Rous sarcoma virus. The human c-src gene is located at 20g12-13 on the long arm of chromosome 20.
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Hence, we used the c-Src inhibitor PP2 to evaluate the involvement of c-Src in gene transcription stimulated by atrazine and E2 in BG-1 cells (see Supplemental Material, Table S3) and 2008 cells (data not shown).
Mda-9/syntenin was originally cloned in Fisher's laboratory, and was shown in previous studies to interact with another protein, c-Src, to start a series of chemical reactions that lead to increased metastasis.
Through mechanisms other than antioxidant function: The non-antioxidant mechanism occurs via two key molecular checkpoints: c-Src and 12-lipoxygenase.
N-ACETYL CYSTEINE FOSTERS INACTIVATION AND TRANSFER TO ENDOLYSOSOMES OF C-SRC.
The targets included focal adhesion kinase (FAK), Pyk2 (a soluble form of FAK), c-Src which can phosphorylate FAK, and the MAP kinases ERK1/2, p38 and JNK.
3] exposure on phosphorylation of Src at tyrosine 416, a specific activation site in the SH1 domain of c-Src (Dorsam et al.
Working on this prior knowledge, a UCSD team led by Michael Karin speculated that something in cell membranes must be able to differentiate between saturated and unsaturated fats, activating or deactivating Jun kinases and in their new study, the team ultimately identified yet another enzyme, called c-Src, which resides within a cell membrane.
622 Discovery and characterization of a novel multi-targeted tyrosine kinase inhibitor with activity against c-Ret, PDGFR, c-Kit and c-Src
The protein tyrosine kinases, c-Src, c-Abl, and Her2/neu, have been implicated convincingly in human cancer and are well validated cell signaling targets for treating cancer.
To test the contributions of each pathway we measured mRNA expression of the genes c-Src, C/EBP[alpha], NF[kappa]B, and GLUT4 in adipose tissue.
The targets included c-src which can activate focal adhesion kinase (FAK), PYK2, a soluble form of FAK, and the MAP kinases ERK 1/2, p38 and SAPK/JNK, which can upregulate cytokines that upregulate MMPs.