c-Rel


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c-Rel

A member of the NF-kappaB family of transcription factors encoded by REL on chromosome 2p13-p12, which is distinguished by the presence of an N-terminal Rel homology domain.

Significance
c-Rel overexpression causes downregulation of EPHB2 (an ephrin receptor tyrosine kinase in the intestine), and is associated with a poor prognosis in colorectal carcinoma.
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References in periodicals archive ?
Band 2 composition, appears to be more complex, however, with RelA, p50, and c-Rel present at all time points.
a) Band RelA (p65) p50 c-Rel p52 1 [check] [check] X X 2 [check] [check] [check] ?
californicus induces the nuclear binding activity of a well-known transcription factor NF-[kappa]B, including one complex with c-Rel and some unidentified subunits.
Indeed, recent gene knockout studies provided convincing evidence that a deficiency in B cells occurred when the genes nfkb1 (p50/p105), nfkb2 (p52/p100), and c-rel were disrupted.
In human lung cancer, NF-[kappa]B p50 and c-Rel were found highly expressed in fresh human non-small cell lung carcinoma tissues and cell lines (75).
Similarly, some groups have identified rearrangement of the c-rel gene in numerous non-Hodgkin lymphomas (83).
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.
Germline configuration of nfkb2, c-rel and bcl3 in childhood acute lymphoblastic leukemia (ALL).