KITLG

(redirected from c-Kit ligand)

KITLG

A gene on chromosome 12q22 that encodes KIT tyrosine kinase receptor ligand, which plays a key role in regulating cellular activities (such as: cell survival and proliferation; haematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis) by activating multiple signalling pathways.

Molecular pathology
KITLG mutations cause familial progressive hyperpigmentation.
References in periodicals archive ?
Normal mast cell proliferation, survival, differentiation, and activation are dependent on binding of stem cell factor or c-KIT ligand to the KIT receptor.
The study showed that men with two copies of the common version of the c-KIT ligand (KITLG) gene were 4.
9, 10) The c-Kit ligand is an early hematopoietic growth factor and mast cell growth factor.
The protooncogene c-kit and c-kit ligand in human disease.
The proto-oncogene c-kit and c-kit ligand in human disease (update on cells and cytokines).