KRAS

(redirected from c-Ki-ras)

KRAS

A Kirsten ras oncogene homolog from the mammalian ras gene family on chromosome 12p12.1, which encodes a small GTPase in which a single amino acid substitution results in a transforming protein.

Molecular pathology
The KRAS transforming protein has been linked to various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas, colorectal carcinoma, acute myelogenous leukaemia, juvenile myelomonocytic leukaemia, gastric cancer, pilocytic astrocytoma, Noonan syndrome type 3, and cardiofaciocutaneous syndrome
References in periodicals archive ?
Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation.
Detection of c-Ki-ras mutations by PCR/RFLP analysis and diagnosis of pancreatic adenocarcinomas.
Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes.
Four human carcinoma cell lines with novel mutations in positions 12 of c-Ki-ras oncogene.
Analysis of c-Ki-ras mutations in human colon carcinoma by cell sorting, polymerase chain reaction, and sequencing.