The contribution of redox imbalance in MAL-A induced cytotoxicity was confirmed by pre-incubating cells with an antioxidant, N-acetyl-L-cysteine (NAC) or a thiol depletor, buthionine sulfoximine
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combina- tion with the glutathione synthesis inhibitor buthionine sulfoximine
in cell line models for HIV-1 quiescence.
And the inhibitor of de novo GSH synthesis, buthionine sulfoximine
, is known to be able to produce oxidative stress.
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine
(BSO)-mediated improvement in cultured embryo quality in vitro entails changes in ascorbate metabolism, meristem development and embryo maturation.
The researchers then repeated the experiment adding a drug inducing oxidative stress, buthionine sulfoximine
protects the viability of adult rat Leydig cells exposed to ethane dimethanesulfonate.
The deleterious effect of buthionine sulfoximine
, a glutathione-depleting agent, on the cisplatin toxicity in mice.
Depletion of intracellular GSH by buthionine sulfoximine
decreases the proportion of CD[8.
1971 In vitro cytotoxicity of HMAF with Monday AM and without buthionine sulfoximine
against Exhibit Hall A-B, #16 drug-resistant tumor cell lines with elevated glutathione
5 SCIENCE, investigators say two drug-resistant, malignant cell lines became three to four times more sensitive to a common cancer drug, adriamycin, after being treated with an inhibitor called buthionine sulfoximine
that blocks the glutathione redox cycle.
GT1-7 cells exhibit a high sensitivity to oxidative stress induced by chemical agents that deplete GSH levels, such as buthionine sulfoximine
and diethylmaleate, which lead to free-radical-mediated cell death (Kane et al.