buthionine sulfoximine

buthionine sulfoximine

A compound that inhibits gamma-glutamyl cysteine synthetase, which is required in the first step of glutathione synthesis; it is used in oncology to reduce glutathione levels and in tropical medicine to increase the susceptibility of parasite to oxidative agents.

bu·thi·o·nine sul·fox·i·mine

(byū-thī'ō-nēn sŭl-fok'si-mēn)
A compound that decreases intracellular glutathione by inhibition of its synthesis.
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reported that injection of melatonin (4 mg/kg, ip) into newborn rats with developed cataracts by buthionine sulfoximine as the inhibitor of glutathione synthesis decreased the incidence of cataract and increased the total glutathione levels significantly in the lens.
The contribution of redox imbalance in MAL-A induced cytotoxicity was confirmed by pre-incubating cells with an antioxidant, N-acetyl-L-cysteine (NAC) or a thiol depletor, buthionine sulfoximine (BSO).
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combina- tion with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence.
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butylhomocysteine sulfoximine).
Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine.
Buthionine sulfoximine (BSO)-mediated improvement in cultured embryo quality in vitro entails changes in ascorbate metabolism, meristem development and embryo maturation.
The researchers then repeated the experiment adding a drug inducing oxidative stress, buthionine sulfoximine (BSO).
Buthionine sulfoximine protects the viability of adult rat Leydig cells exposed to ethane dimethanesulfonate.