buthionine sulfoximine

buthionine sulfoximine

A compound that inhibits gamma-glutamyl cysteine synthetase, which is required in the first step of glutathione synthesis; it is used in oncology to reduce glutathione levels and in tropical medicine to increase the susceptibility of parasite to oxidative agents.

bu·thi·o·nine sul·fox·i·mine

(byū-thī'ō-nēn sŭl-fok'si-mēn)
A compound that decreases intracellular glutathione by inhibition of its synthesis.
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References in periodicals archive ?
The contribution of redox imbalance in MAL-A induced cytotoxicity was confirmed by pre-incubating cells with an antioxidant, N-acetyl-L-cysteine (NAC) or a thiol depletor, buthionine sulfoximine (BSO).
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combina- tion with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence.
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butylhomocysteine sulfoximine).
Buthionine sulfoximine (BSO)-mediated improvement in cultured embryo quality in vitro entails changes in ascorbate metabolism, meristem development and embryo maturation.
The researchers then repeated the experiment adding a drug inducing oxidative stress, buthionine sulfoximine (BSO).
Buthionine sulfoximine protects the viability of adult rat Leydig cells exposed to ethane dimethanesulfonate.
The deleterious effect of buthionine sulfoximine, a glutathione-depleting agent, on the cisplatin toxicity in mice.
1971 In vitro cytotoxicity of HMAF with Monday AM and without buthionine sulfoximine against Exhibit Hall A-B, #16 drug-resistant tumor cell lines with elevated glutathione
5 SCIENCE, investigators say two drug-resistant, malignant cell lines became three to four times more sensitive to a common cancer drug, adriamycin, after being treated with an inhibitor called buthionine sulfoximine that blocks the glutathione redox cycle.
GT1-7 cells exhibit a high sensitivity to oxidative stress induced by chemical agents that deplete GSH levels, such as buthionine sulfoximine and diethylmaleate, which lead to free-radical-mediated cell death (Kane et al.