busulphan

busulphan

Busulfan, an alkylating anticancer drug used especially in the treatment of chronic granulocytic LEUKAEMIA. It is very toxic and can destroy the function of the BONE MARROW unless its use is carefully monitored. It can also cause widespread FIBROSIS of the lungs. A brand name is Myleran.
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Tenders are invited for Rate Contract for Tablets- 6-Mercaptopurine, Acenocoumarol Acetazolamide, Acyclovir, Allopurinol, Altretamine, Aminophyline, Amitryptyline, Anastrazole, Antacid Tablet (Aluminium Hydroxide + Magnesium Aluminium Silicate+Magnesium Hydroxide, + Simethicone), Artesunate, Atorvastatin, Atorvastatin, Azathioprine, Azithromycin, Betahi stine, Bicalutamide, Buproprion, Busulphan, Cabergolin, Capecitabine, Carbamazepine, Cefixime, Chlorpromazine, Chlorpromazine Hydrochloride.
3) Table 3: Activity of 21 antineoplastic agents against 4 groups of pathogenic microorganisms, expressed in semiquantitative terms Activity against indicated type of organism Gram- Gram- Antineoplastic positive negative Agent bacteria bacteria Alkylating agents Carmustine 0 0 Chlorambecil 0 0 Neoplatin 0 + No activity shown by busulphan, cyclophosphamide, dibromomannitol, and melphalan.
The most commonly used regimes in children are the regimes in which cyclophosphamide and busulphan are used together (23).
Trade names Generic names Dosage form Strengths Mvleran Busulphan Tablet 2mg/Tablet Leukeran Chlorambucil Tablet 2mg/Tablet Endoxan Cyclophosphamide White Powder 200mg/Vial Anhvdrous Injection Endoxan Cyclophosphamide White Powder 500mg/Vial Anhydrous Injection Endoxan Cyclophosphamide White Powder 1gm/Vial Anhydrous Injection Endoxan Cyclophosphamide Tablet 50mg/Tablet Anhydrous Holoxan Ifosfamide Injection 1gm/Vial Holoxan Ifosfamide Injection 2gm/Vial Alkeran Melphalan Tablet 2mg/Tablet Uromitexan Mesna Injection 100mg/ml.
busulphan, cyclophosphamide and dacarbazine) are DNA-damaging treatments, affecting both cancer and healthy cells.
Variability in the pharmacokinetics of intravenous busulphan given as a single daily dose to paediatric blood or marrow transplant recipients.
Reduced-intensity allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia with multilineage dysplasia using fludarabine, busulphan, and alemtuzumab (FBC) conditioning.
62) Vitamin C has been shown in either animal or human studies to either increase the efficacy and/or decrease the toxicity of the following chemotherapeutic agents: alkylating agents (cyclophosphamide, ifosfamide, busulphan, melphan), antibiotic type agents (doxorubicin (adriamycin), bleomycin, epirubicin, daunorubicin), anti-metabolites (5-Fluorouracil, methotrexate), platinum compounds (cisplatin), radiotherapy, hormone therapies (tamoxifen), and plant alkaloids (etoposide, vincristine, paclitaxel).
Treatment of mice with the toxic drug busulphan, which selectively kills male germline stem cells, depleted the follicle pool but did not induce atresia.
Third, treatment of mice with the toxic drug busulphan, which selectively kills male germline stem cells, depleted the follicle pool but did not induce atresia.
The testis has been reported to be damaged by commercial malathion according to Wenda-Rozewicka (1983); the response is similar to that observed after treatment with busulphan (van Keulen & De Rooij, 1973) or X-rays (Dym & Clermont, 1970).
Abacavir 60mg + Lamivudine 30 mg Tab, Activated Charcoal IP, Acyclovir eye ointment 5gm, Adefovir Dipivoxil Tablets / Capsules 10 mg, Busulphan Tablets IP 2 mg, Carbimazole Tab.