buspirone hydrochloride


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Related to buspirone hydrochloride: BuSpar

buspirone hydrochloride

BuSpar

Pharmacologic class: Azaspirodecanedione

Therapeutic class: Anxiolytic

Pregnancy risk category B

Action

Unclear. Thought to bind to serotonin and dopamine receptors in CNS, increasing dopamine metabolism and impulse formation. Also thought to inhibit neuronal firing and reduce serotonin turnover.

Availability

Tablets: 5 mg, 7.5 mg, 10 mg, 15 mg, 30 mg

Indications and dosages

Anxiety disorders; anxiety symptoms

Adults: 7.5 mg P.O. b.i.d.; increase by 5 mg/day q 2 to 3 days as needed (not to exceed 60 mg/day). Common dosage is 20 to 30 mg/day in divided doses.

Off-label uses

• Parkinsonian syndrome
• Symptomatic relief of depression

Contraindications

• Hypersensitivity to drug
• Severe renal or hepatic impairment
• MAO inhibitor use within past 14 days

Precautions

Use cautiously in:
• patients receiving concurrent anxi-olytics or psychotropics
• pregnant or breastfeeding patients
• children.

Administration

• Give with food to minimize GI upset.
• Know that full benefit of drug therapy may take up to 2 weeks.

Adverse reactions

CNS: dizziness, drowsiness, nervousness, headache, insomnia, weakness, personality changes, numbness, paresthesia, tremor, dream disturbances

CV: chest pain, palpitations, tachycardia, hypertension, hypotension

EENT: blurred vision, conjunctivitis, tinnitus, nasal congestion, sore throat

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dry mouth

GU: dysuria, urinary frequency or hesitancy, menstrual irregularities, menstrual spotting, libido changes

Musculoskeletal: myalgia

Respiratory: chest congestion, hyperventilation, dyspnea

Skin: rash, alopecia, blisters, pruritus, dry skin, easy bruising, edema, flushing, clammy skin, excessive sweating

Other: altered taste or smell, fever

Interactions

Drug-drug.Erythromycin, itraconazole: increased buspirone blood level

MAO inhibitors: hypertension Trazodone: increased risk of adverse hepatic effects

Drug-food.Grapefruit juice: increased buspirone blood level and effects

Drug-herbs.Hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors.Alcohol use: increased CNS depression

Patient monitoring

• Monitor mental status closely.
• Assess hepatic and renal function regularly to detect drug toxicity.

Patient teaching

• Instruct patient to take drug with food.
• Advise patient not to use drug to manage everyday stress or tension.
• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Caution patient to avoid alcohol because it increases CNS depression.
• Emphasize importance of keeping follow-up appointments to check progress.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, foods, herbs, and behaviors mentioned above.

bu·spi·rone hy·dro·chlor·ide

(bū-spī'rōn hī'drō-klōr'īd),
Azaspirodecanedione; antianxiety agent used to manage anxiety disorders or for short-term relief of the symptoms of anxiety.

busPIRone hydrochloride

[boo͡spir′ōn]
an antianxiety agent not related chemically to others. Administered orally as the hydrochloride salt. Unlike benzodiazepines, does cause sedation, has low abuse potential, takes several days to weeks to exert its effect, and does not intensify the effects of other CNS depressants.
indications It is prescribed for generalized anxiety disorders.
contraindications This drug is contraindicated in patients with severe hepatic or renal impairment. Patients taking a benzodiazepine drug should be gradually withdrawn from that medication before starting therapy with buspirone.
adverse effects Among adverse reactions reported are dizziness, headache, lightheadedness, excitement, and nausea.

buspirone hydrochloride

(bū-spī′rōn″)
An antianxiety agent that is neither a benzodiazepine nor a barbiturate. It has minimal central nervous system depressant actions, produces minimal sedation, and does not enhance the depressant effects of alcohol and other central nervous system depressants. The drug is used in treating short-term anxiety.
References in periodicals archive ?
Buspirone Hydrochloride Tablets are the generic equivalent of Bristol-Myers Squibb's Buspar(R) Tablets for the treatment of anxiety.
On the eve of the patent's expiration, however, Bristol-Myers Squibb obtained a new patent that covered a chemical compound (known as a metabolite) that is created by the human body after ingestion of buspirone hydrochloride.
The suit claims that in 1998 Pittsburgh-based Mylan Laboratories submitted an Abbreviated New Drug Application to the FDA to produce a generic version of buspirone hydrochloride tablets immediately after BMS's November 21, 2000 patent expired.
6,150,365 entitled Anxiety Method, will not be infringed by the manufacture, use or sale of Mylan's tentatively-approved generic buspirone hydrochloride product.
Additionally, the FDA has given tentative approvals to the company's ANDA's for ranitidine tablets in 75 mg dose form and to buspirone hydrochloride tablets in 5 mg, 10 mg, and 15 mg dose form.