bullous pemphigoid


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pemphigoid

 [pem´f…………ĭ-goid]
1. resembling pemphigus.
2. any of a group of skin disorders similar to but clearly distinguishable from pemphigus.
benign mucosal pemphigoid a chronic bullous disease of elderly persons, involving primarily the mucous membranes, particularly the conjunctiva and oral mucosa, with scarring.
bullous pemphigoid a usually mild, relatively benign, self-limited blistering skin disease, predominantly affecting elderly persons. IgE antibodies are found at the basement membrane.
localized chronic pemphigoid a form in which bulla formation is confined for many years to a circumscribed region, with scarring but without affecting the mucous membranes.

bul·lous pem·phi·goid

a chronic, generally benign disease, most commonly of old age, characterized by tense nonacantholytic bullae in which serum antibodies are localized to hemidesmosomal components of the epidermal basement membrane, causing detachment of the entire thickness of the epidermis.

bullous pemphigoid

Etymology: L, bulla, bubble; Gk, pemphix, bubble, eidos, form
a rare, relatively benign subepidermal autoimmune blistering disease of the elderly. It is of unknown origin.
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Bullous pemphigoid

bullous pemphigoid

An acquired immunobullous disease characterised by subepidermal bullae formation, linked to deposition of IgG and C3 at the basement membrane in the groin, axilla, scalp, legs and oral cavity.

Increased risk
Immune-mediated diseases—e.g., rheumatoid arthritis, lupus erythematosus, psoriasis, primary biliary cirrhosis, diabetes.
 
DiffDx
Arthropod reactions, bullous amyloidosis, diabetic bullous disease, bullous impetigo, dermatitis herpetiformis, erythema multiforme, epidermolysis bullosa aquisita, linear Ig A disease, pemphigus vulgaris, porphyria cutanea tarda, suction blister.

Pemphigoid variants
Major
• Bullous pemphigoid;
• Mucous membrane (cicatricial) pemphigoid;
• Pemphigus gestationis.

Minor
• Drug induced;
• Lichen planus pemphigoides;
• Paraneoplastic pemphigoid;
• Pemphigoid nodularis;
• Pemphigoid vegetans.

bullous pemphigoid

Dermatology A disease characterized by tense blister–bullae formation on mucocutaneous surfaces, caused by circulating antibodies–usually IgG to the basement membrane of stratified epithelium Clinical BP may be chronic and mild without affecting the general health Management Topical corticosteroids–may require high doses of systemic cortisone. Cf Pemphigus vulgaris.

bul·lous pem·phi·goid

(bul'ŭs pem'fi-goyd)
A chronic, generally benign disease, most commonly of old age, characterized by tense nonacantholytic bullae in which serum antibodies are localized to the epidermal basement membrane, causing detachment of the entire thickness of the epidermis.

bullous pemphigoid

A skin disease of elderly people that features large tense blisters. The condition is caused by an immunological disorder and usually responds well to steroids or immunosuppressive treatment.

bullous pemphigoid

autoimmune disease of the elderly, characterized by epidermal-dermal separation, blood-filled blisters and skin erosions; treated by oral corticosteroids

bullous

pertaining to or characterized by bullae.

bullous emphysema
pulmonary emphysema characterized by the presence of subpleural and interlobular bullae.
bullous epidermolysis
see epidermolysis bullosa.
bullous pemphigoid
see bullous pemphigoid.

pemphigoid

1. resembling pemphigus.
2. a group of skin disorders similar to but clearly distinguishable from pemphigus.

bullous pemphigoid
an autoimmune disease of skin and oral mucosa with vesicles, bullae and ulcerations; occurs rarely in dogs and humans.
cicatricial pemphigoid
a form that involves the oral and ocular mucosa.
References in periodicals archive ?
Lee JJ, Downham TF 2nd: Furosemide-induced bullous pemphigoid, case report and review of literature.
BP230- and BP180-specific auto-antibodies in bullous pemphigoid.
Lamb PM, Abell E, Tharp M, Frye R, Deng JS: Prodromal bullous pemphigoid.
Joly P, Roujeau JC, Benichou J, Picard C, Dreno B, Dellaporte E, et al; Bullous Diseases French Study Group: A comparison of oral and topical corticosteroids in patients with bullous pemphigoid.
Bullous pemphigoid occurring during efalizumab treatment for psoriasis: A paradoxical auto-immune reaction?
Tsuji-Abe Y, Akiyama M, Yamanaka Y, Kikuchi T, Sato-Matsumura KC, Shimizu H: Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid.
The Company expects to begin trials in late 2013 for the treatment of bullous pemphigoid, a rare auto-immune condition that affects the skin and causes the formation of blisters.
These cells play a role in the development of certain inflammatory diseases, including Crohn's disease, ulcerative colitis, severe asthma and bullous pemphigoid.
We believe that Immune's recent announcement on securing these financings will provide the resources needed to allow completion of our recently initiated Phase II clinical trials of Bertilimumab, a first in class monoclonal antibody, for the treatment of Bullous Pemphigoid and Ulcerative Colitis, and the initiation of pilot studies for additional indications such as Crohn's disease, NASH, and severe asthma," stated Dr.
These financing agreements offer a vote of confidence from two institutional investors, Hercules and Discover, in support of clinical development for our drug candidate, bertilimumab, in bullous pemphigoid and ulcerative colitis", said Dr.
patients in our Phase II clinical trial in bullous pemphigoid, an orphan auto-immune disease of the skin, and starting to enroll patients in the Phase II clinical trial in moderate to severe ulcerative colitis, a serious immuno-inflammatory condition of the gastro-intestinal tract.
Food and Drug Administration (FDA) has approved its Investigational New Drug (IND) application for its first in class, lead product candidate, Bertilimumab, to treat Bullous Pemphigoid (BP).