bulky disease

bulky disease

term used for large tumors or lymph nodes; usually more resistant to conventional therapy.
A term for a cancer with a considerable tumour burden—‘bulk’; bulky disease generally has a poorer prognosis independent of the histologic grade; a major priority in oncology is to debulk a tumour to optimise chemo- or radiation therapy

bulky disease

Oncology A term for a CA with a considerable tumor burden–'bulk'; BD generally has a poorer prognosis independent of the histologic grade; a major priority in oncology is to debulk a tumor to optimize chemo- or RT. See Debulking operation.
References in periodicals archive ?
Categorical data such as gender, LDH, extra nodal site involvement, bone marrow Involvement, bulky disease, IPI score, stage of disease, chemotherapy, response to chemotherapy were presented as frequency and percentage.
Bulky disease has an impact on outcomes in primary diffuse large B-cell lymphoma of the breast: a retrospective analysis at a single institution.
Patient's demographics, clinical characteristics at presentation like Ann Arbor stage, IPI, presence of bulky disease, baseline and follow-up imaging, biopsy results from residual masses, response to therapy, and survival duration were recorded.
While experimental, for women with bulky disease (greater than 2 cm), neoadjuvant chemotherapy and subsequent trachelectomy has been reported (Gynecol.
This breath analysis method presents the potential for a cheaper and more reliable diagnostic option for patients found to have bulky disease on a CT scan.
The following baseline clinical characteristics were recorded: sex, age, stage, presence of bulky disease or B symptoms, performance status and blood counts.
Data showed an antitumour activity in HL patients progressing after stem cell transplantation (SCT) with bulky disease in about a third of patients within two cycles of therapy.
Bulky disease was defined as the presence of a nodal mass greater than 10 cm in diameter.
Patients received radiotherapy (36 Gy) to sites of initial bulky disease and extranodal disease.
Patients with bulky disease may require neoadjuvant chemotherapy and/or primary interval cytoreduction.