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Bulky Disease |
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Bulky Disease A term for a cancer with a considerable tumour burden—‘bulk’; bulky disease generally has a poorer prognosis independent of the histologic grade; a major priority in oncology is to debulk a tumour to optimise chemo- or radiation therapy
bulky disease Oncology A term for a CA with a considerable tumor burden–'bulk'; BD generally has a poorer prognosis independent of the histologic grade; a major priority in oncology is to debulk a tumor to optimize chemo- or
RT. See Debulking operation. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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Patients with bulky disease may require neoadjuvant chemotherapy and/or primary interval cytoreduction. In 26 patients with 31 EMPs, locoregional tumor control, with radiation alone, was limited by poor performance status, treatment fields (from previous radiation therapy), or concurrent illness in patients with bulky disease. The 5-year survival rate of 42% in our patients with occult N2 disease (10) is matched by results reported from Memorial Sloan-Kettering (11) and Tufts, (12) in contradistinction to the vast majority of patients with stage N2 disease (90%) who have bulky disease, in whom the 3-year survival rate may be less than 10%. |
Bulky Disease |
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