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bulky disease |
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bulky disease Oncology A term for a CA with a considerable tumor burden–'bulk'; BD generally has a poorer prognosis independent of the histologic grade; a major priority in oncology is to debulk a tumor to optimize chemo- or
RT. See Debulking operation. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Patients with bulky disease may require neoadjuvant chemotherapy and/or primary interval cytoreduction. Unfortunately there is a subset of stage 3B patients with bulky disease, bilateral hydronephrosis or impaired renal failure who will have a poor outcome after radiotherapy and may be palliated rather by short-course radiotherapy. The 5-year survival rate of 42% in our patients with occult N2 disease (10) is matched by results reported from Memorial Sloan-Kettering (11) and Tufts, (12) in contradistinction to the vast majority of patients with stage N2 disease (90%) who have bulky disease, in whom the 3-year survival rate may be less than 10%. |
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