While experimental, for women with bulky disease
(greater than 2 cm), neoadjuvant chemotherapy and subsequent trachelectomy has been reported (Gynecol.
This breath analysis method presents the potential for a cheaper and more reliable diagnostic option for patients found to have bulky disease
on a CT scan.
The overall response to ibrutinib was independent of prior treatment including bortezomib and lenalidomide or underlying risk/prognosis, bulky disease
, gender or age.
was defined as the presence of a nodal mass greater than 10 cm in diameter.
He had massive hepatosplenomegaly and widespread enlarged lymph nodes with a mediastinal bulky disease
Patients with bulky disease
may require neoadjuvant chemotherapy and/or primary interval cytoreduction.
The other risk factors were a prostate-specific antigen (PSA) score greater than 10 ng/mL, a biopsy Gleason score of 7 or higher, the presence of bulky disease
on endorectal MRI, a palpable nodule, and either multiple positive biopsy cores or a high percentage of tumor on biopsy cores.
In 26 patients with 31 EMPs, locoregional tumor control, with radiation alone, was limited by poor performance status, treatment fields (from previous radiation therapy), or concurrent illness in patients with bulky disease
Thirty percent of LTR patients had bulky disease
(tumor size greater than five centimeters) and 83 percent had stage III/IV disease.
The 5-year survival rate of 42% in our patients with occult N2 disease (10) is matched by results reported from Memorial Sloan-Kettering (11) and Tufts, (12) in contradistinction to the vast majority of patients with stage N2 disease (90%) who have bulky disease
, in whom the 3-year survival rate may be less than 10%.
0 mm, explaining the poor results with retained bulky disease
Three of the four patients with bulky disease
responded to the regimen.