bufadienolide


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bu·fan·o·lide

(bū-fan'ō-līd),
The fundamental steroid lactone of several vegetable (for example, squill) and animal (for example, toad) venoms or toxins; also found in the form of glycosides in plants (for example, digitalis).

bufadienolide

group of toxic cardiac glycosides found mainly in members of Crassulaceae family, e.g. Cotyledon, Tylecodon, Bryophyllum spp. Found also in skin and skin glands of toads, e.g. Bufo marinus. Those in Cotyledon and Tylecodon are cumulative and produce krimpsiekte (cotyledonosis).
References in periodicals archive ?
The toxicity to cattle and bufadienolide content of six Bryophyllum species.
It has to be noted that, compared to cinnamic acids and flavonoids, most bufadienolides show lower UV absorbances (low [epsilon] values) at the detection wavelength of 298 nm.
Antitumor agents, 1101,2 bryophyll in B, a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum.
Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pinnatum.
An endogenous bufadienolide inhibitor of sodium pump, marinobufagenin, has also been shown to be increased in HF, and its plasma concentrations seem to correlate with severity of disease (65).
Preliminary data suggest that the bufadienolide content in the chewable tablets used in the present study was less than 0.
Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that is independent of cholesterol side-chain cleavage.
Simultaneous determination of cytotoxic bufadienolides in the Chinese medicine ChanSu by high-performance liquid chromatography coupled with photodiode array and mass spectrometry detections.
Since the island has no poisonous toads, Mori proposed that the snakes need to eat toads to have the defensive toxins, called bufadienolides.