bryostatin


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bryostatin

Any of a group of 20 different macrolide lactones isolated from a species of bryozoans (moss animals), a phylum of aquatic invertebrates (Bugula neritina), which upregulate protein kinase C (PKC) activity in the short term, and downregulate PKC with prolonged exposure. Bryostatin I inhibits cell growth and angiogenesis, drives cell differentiation and apoptosis and has immunomodulatory activity. While it showed promise as a memory enhancer and in cancer management, it failed as a monotherapy in phase-II clinical trials.
 
Adverse effects
Myalgia.
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the Company's wholly-owned subsidiary, has an exclusive license to develop and commercialize bryostatin, a potent modulator of an enzyme called protein kinase C epsilon (PKCe), which has been studied extensively by the Blanchette Rockefeller Neurosciences Institute (BRNI) as a possible treatment of cognitive disorders.
Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula," the uncultivated microbial symbiont of the marine bryozoan Bugula neritina.
The molecule, named bryostatin 1, was deemed to hold promise as a treatment, not only for HIV but for cancer and Alzheimer's disease as well.
The Food and Drug Administration (FDA) has recently given the approval for Bryostatin to enter Phase II clinical trials for not only the treatment of Alzheimer's disease but also its underlying causes.
Treatments of Bryostatin and similar compounds synthesized at BRNI that target the enzyme PKC, which controls the creation of synapses at the molecular level, were administered for twelve weeks during the study.
Our novel approach, dubbed pharmaceutical agriculture, has also been successfully applied to the marine natural products bryostatin and ET743.
It takes 14 tonnes of bugula from the ocean to extract only one ounce of a substance called bryostatin to make the treatment.
Similarities between the sensitivity to 2-chlordeoxyadenosin of lymphocytes for CLL patients and bryostatin 1 treated WSU-CLL cells: an infrared spectroscopic study.
Hornung RI, Pearson JW, Beckwith M, Longo DI (1992) Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity.
The agent, bryostatin 1, is obtained by grinding and purifying a small sea creature called Bugula neritina.
its wholly-owned operating subsidiary, (the "Company") will be showcasing bryostatin as a potential treatment for Alzheimer's Disease at the Alzheimer's Association International Conference(R)(AAIC) being held July 18-23, 2015, in Washington, DC.