bronchocentric granulomatosis

bronchocentric granulomatosis

A condition characterised by granulomatous replacement of mucosa with eosinophilia and sometimes angiitis, due either to a fungal—allergic bronchopulmonary aspergillosis—or tuberculosis reaction, or hypersensitivity to various antigens.

Age
Young, ± age 22 years. Patients typically present with asthma and eosinophilia, neither of which is commonly seen in older patients.

bronchocentric granulomatosis

Chest medicine A condition characterized by a granulomatous replacement of mucosa with eosinophilia and sometimes angiitis, due either to a fungal–allergic bronchopulmonary aspergillosis–or TB reaction or hypersensitivity to various antigens Age grouping Young–± age 22 yrs, typical Sx of asthma and eosinophilia; older group with neither Clinical Progressive dyspnea, cough, hemoptysis, malaise, fever; cavities may result from lung abscesses, cavitated granulomas, distended bronchi; 75% of BGs are unilateral, and more common in upper lobes Imaging Lobar and segmental consolidation and atelectasis, irregular masses, linear opacities, shadows due to abnormal bronchi, mucoid impaction. See Allergic bronchopulmonary aspergillosis.

bron·cho·cen·tric gran·u·lo·ma·to·sis

(brong'kō-sen'trik gran'yū-lō'mă-tō'sis)
A severe form of allergic bronchopulmonary aspergillosis.
References in periodicals archive ?
Bronchocentric granulomatosis is characterized by necrotizing granulomas centered exclusively on bronchi and bronchioles distal to the bronchi affected by mucoid impaction (Figure 4, C).
Bronchocentric granulomatosis refers to the presence of necrotizing granulomas centered exclusively on bronchi and bronchioles.
To summarize, bronchocentric granulomatosis is best thought of as an unusual and distinctive tissue reaction seen predominantly in allergic bronchopulmonary fungal disease and various other infections, rather than as the discrete entity that Liebow135 had originally envisioned.
Granulomatous infection mimicking bronchocentric granulomatosis.
Bronchocentric granulomatosis, mucoid impaction, and hypersensitivity reactions to fungi.
Eosinophilic lung diseases Allergic syndromes Allergic bronchopulmonary aspergillosis Allergic bronchopulmonary syndromes associated with fungi Bronchocentric granulomatosis Associated with parasitic infestation Tropical eosinophilia (filariasis) Ascaris spp.
Potential Etiologies of Acute and Chronic Bronchiolitis (a) Viral infection Bacterial infection Mycoplasma infection Hypersensitivity pneumonitis Respiratory bronchiolitis Aspiration pneumonia Pulmonary involvement with collagen vascular disease Posttransplantation, graft-versus-host disease Wegener granulomatosis Bronchocentric granulomatosis Diffuse panbronchiolitis Inhalation of fumes and toxins Asthma Inflammatory bowel disease-related small airways disease Idiopathic (a) Data were derived from Cagle et al.
Our patient also appears to have had bronchocentric granulomatosis by pathology.
Bronchocentric granulomatosis (BCG), first described by Liebow in 1973,[1] consists of filling of the lumen of a bronchiole with dense plugs of mucus and cellular debris, necrosis of mucosa, and its replacement by polymorphous inflammation and radially palisaded epithelioid histiocytes.
Bronchocentric granulomatosis can present radiologically as a single mass, as multiple masses, or as a more diffuse disease.
3] Bronchocentric granulomatosis with eosinophilia typically occurs in asthmatic patients and may be associated with intrabronchial Aspergillus or rarely with other organisms.
13] Bronchocentric granulomatosis in one patient with rheumatoid arthritis was thought to represent a widespread immunologic response and not a distinct entity.