In patients with 2 consecutive available lung samples (taken before and after the clinical occurrence of PHT), pulmonary vasculopathy worsened, whereas parenchymal and bronchiolar
lesions remained unchanged.
However, in most patients with folded bronchiolar
epithelium there is no airway obstruction, except in airway-related diseases such as asthma and constrictive bronchiolitis, where other characteristics (increased luminal mucus, inflammation, thickened basement membrane, and/or fibrosis) explain the obstruction.
Focusing on data provided by the above-cited series of 10 patients or more, it is apparent that although the terminology differs, a common histopathologic denominator emerges in the variable amount of bronchiolar
and peribronchiolar fibrosis and inflammation (Table 4).
Alveolar-cell carcinoma (terminal bronchiolar
carcinoma): a study of surgically excised tumors with special emphasis on localized lesions.
At 3, 6, and 9 dpi, large amounts of influenza A virus antigen were found in bronchial and bronchiolar
epithelium and lumens (Figure 3, panel F).
Although 1-NN causes both centrilobular liver damage and bronchiolar
epithelial damage in rats, the lung is the primary target tissue.
Hyperinflation and linear markings are radiologic evidence of bronchiolar
, peribronchiolar, and/or alveolar duct inflammation (Calderon-Garciduenas et al.
Normal parenchyma, including normal appearing pneumocytes and bronchiolar
metaplasia surrounding a tumor showed positivity for phospho-mTOR expression in only 25.
CYP1A1 expression was seen also in chondrocytes and bronchiolar
epithelium but was not seen in type 1 or type 2 pneumocytes [see supplementary material (http://ehp.
Serosanguinous exudate was seen throughout the tracheal and bronchiolar
lumen, and pleural effusion was also seen.
Thyroid transcription factor 1 (TTF-1), a nuclear transcription factor that is expressed in the developing forebrain, thyroid epithelium, and fetal lung epithelial cells, is expressed in normal adult bronchiolar
and alveolar epithelium as well as many pulmonary neoplasms, including small cell carcinomas (11) and adenocarcinomas.
Exposure to cobalt sulfate causes alveolar/ bronchiolar
neoplasms both in rats and in mice (Bucher et al.