Korea is the first Asian country that Pharmaxis has filed a New Drug Application, and was chosen because of the high patient numbers and acceptance of bronchial provocation
tests in diagnosing and managing respiratory disease.
Elsewhere, oral or bronchial provocation
with different doses of aspirin is common.
Subsequently, all subjects were given a standard bronchial provocation
test, during which they inhaled five breaths of increasing concentrations of allergens.
It is equally thrilling to be bringing a truly Australian-made pharmaceutical discovery to the world -- and the first indirect bronchial provocation
test registered in Europe.
The study will examine safety and tolerability, as well as the effectiveness of the various dose levels on improving lung function and reducing airway inflammation, as measured by spirometry tests, exhaled nitric oxide levels, biomarkers in sputum, as well as bronchial provocation
Subjects were randomised to receive either inhaled Pumactant or a placebo before receiving a standard bronchial provocation
test, inhaling five breaths of increasing concentrations of allergens.
Nasal provocation can be eschewed in favor of bronchial provocation
, but the upper airway test has several distinct advantages.