bromocriptine


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Related to bromocriptine: Cabergoline

bromocriptine

 [bro″mo-krip´tēn]
an ergot alkaloid that acts as a dopamine agonist; used as the mesylate salt to suppress prolactin secretion in the treatment of pituitary prolactinomas and of hyperprolactinemia-associated amenorrhea, galactorrhea, infertility, or male hypogonadism. It is also used as an antidyskinetic, usually in conjunction with levodopa, in the treatment of parkinsonism, and is used as a growth hormone suppressant in the treatment of acromegaly. Administered orally.

bromocriptine

/bro·mo·crip·tine/ (bro″mo-krip´tēn) an ergot alkaloid dopamine agonist, used as the mesylate salt to suppress prolactin secretion and thereby treat prolactinomas and endocrine disorders secondary to hyperprolactinemia; also used as an antidyskinetic in parkinsonism and a growth hormone suppressant in acromegaly.

bromocriptine

(brō′mō-krĭp′tēn)
n.
An ergot alkaloid, C32H40BrN5O5, that is a dopamine antagonist and is used in its mesylate form to treat Parkinson's disease, acromegaly, and excessive prolactin secretion, and to reduce the size of certain pituitary tumors.

bromocriptine

Endocrinology
An ergoline derivative which reduces pituitary prolactin secretion and size of pituitary tumours.
 
Indications
Hyperprolactinemia, pituitary tumours, amenorrhoea, female infertility, hypogonadism, acromegaly, Parkinson’s disease, neuroleptic malignant syndrome, type-2 diabetes.
 
Adverse effects
Orthostatic hypotension, vomiting, vertigo, headaches, upset stomach, coronary vasospasm, pulmonary fibrosis, hepatotoxicity.

Immunology
A dopamine D2-receptor inhibitor which inhibits T-cell-dependent induction of macrophage tumouricidal activity.

bromocriptine

An ERGOT derivative drug with DOPAMINE-like effects. It is used in the treatment of PARKINSON'S DISEASE and ACROMEGALY and given to prevent LACTATION by inhibiting the secretion of the hormone prolactin by the pituitary gland. A brand name is Parlodel.

Bromocriptine

Also known as Parlodel, the main drug used to treat galactorrhea by reducing levels of the hormone prolactin.
Mentioned in: Galactorrhea, Lactation

bromocriptine

a dopamine agonist; as a derivative of ergot alkaloids it is a luteolytic and arbortifacient which suppresses prolactin secretion and lowers plasma ACTH levels. Used as an abortifacient and in the treatment of pituitary-dependent hyperadrenocorticism.
References in periodicals archive ?
5 to and dopa- 400/100 mg/d (17,18) decarboxylase inhibitor (17) Levodopa/carbidopa Dopamine precursor 75/750 mg/d (19) and dopa- decarboxylase inhibitor (16) Bromocriptine Dopamine agonist (20) 5 to 150 mg/d (20-23) Donepezil Cholinesterase 5 to 10 mg/d (24) inhibitor (24) Rivastigmine Cholinesterase 4.
Bromocriptine administration showed improved glucose tolerance and significant reduction in blood glucose in various animal studies which formed the basis for further human testing in T2DM.
Bromocriptine is the next dopamine agonist after cabergoline which evokes interest in recent years, owing to its advantages in patients at risk of OHSS, including its shorter half-life and greater experience with this drug in pregnancy, the lack of teratogenicity, despite side effects such as nausea, headaches and orthostatic dysregulation.
Recovery from postpartum cardiomyopathy in 2 patients by blocking prolactin release with bromocriptine.
Diencephalic seizures: Responsiveness to bromocriptine and morphine.
concluded that patients treated with dantrolene and/or bromocriptine had evidence of NMS for a mean of 9.
Cabergoline treatment rapidly improves gonadal function in hyperprolactinemic males: a comparison with bromocriptine.
Major finding: The proportional reporting ratio, similar to the relative risk ratio, was significant between pramipexole, ropinirole, cabergoline, bromocriptine, rotigotine, and apomorphine on one hand, and a variety of impulse control disorders on the other.
Thanks to the bromocriptine, Paula has made a complete recovery, even though doctors expected her heart to be permanently damaged.
Octreotide Acetate Injection, a Somatostatin Analog, is indicated to reduce blood levels of growth hormone and IGF-I (somatomedin C) in acromegaly patients who have had inadequate response to or cannot be treated with surgical resection, pituitary irradiation, and bromocriptine mesylate at maximally tolerated doses, concluded the company.