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1. destructive of life.
2. a chemical substance produced by a microorganism that has the capacity, in dilute solutions, to kill other microorganisms or inhibit their growth. Antibiotics that are sufficiently nontoxic to the host are used as chemotherapeutic agents in the treatment of infectious diseases. See also antimicrobial agent.
antineoplastic a's (antitumor a's) a class of antineoplastic agents that apparently affect the function or the synthesis, or both, of nucleic acids and thus are cell cycle nonspecific. See also antineoplastic therapy.
broad-spectrum antibiotic one that is effective against a wide range of bacteria, both gram-positive and gram-negative.
an antibiotic having a wide range of activity against both gram-positive and gram-negative organisms.
an antibiotic that is effective against a wide range of infectious microorganisms.
broad-spectrum antibioticA therapeutic array used to treat bacterial infections—e.g., acute otitis media.
Azithromycin, clarithromycin, cefixime, cefpodoxime proxetil, cefprozil, ceftriaxone, cefuroxime axetil, loracarbef.
Overuse of broad-spectrum antibiotics facilitates development of antibiotic-resistant infections and multi-drug resistance.
broad-spec·trum an·ti·bi·ot·ic(brawd-spek'trŭm an'tē-bī-ot'ik)
An antibiotic having a wide range of activity against both gram-positive and gram-negative organisms.
1. destructive of life.
2. a chemical substance produced by a microorganism that has the capacity, in dilute solutions, to kill (biocidal activity) or inhibit the growth (biostatic activity) of other microorganisms. Antibiotics that are sufficiently nontoxic to the host are used as chemotherapeutic agents in the treatment of infectious diseases. See also antimicrobial.
3. used as feed additives to animals as growth promotants.
a group of antibiotics which have a tetracycline ring structure substituted with the sugar daunosamine. Includes the antineoplastic drugs doxorubicin and daunorubicin.
one that kills bacteria.
one that suppresses the growth of bacteria.
one that is effective against a wide range of bacteria.
on-farm and prepackaged laboratory tests available for testing farm products and animal tissues and fluids for antibiotic residues.
antibiotic feed additives
see feed additives.
first generation antibiotic
one produced as a natural product, e.g. penicillin G. See second generation antibiotic (below).
antibiotic food preservation
is a satisfactory technique but very strictly controlled because of the problem of residues in the food. Used mostly for the preservation of fish.
see pseudomembranous colitis, acute undifferentiated diarrhea of the horse.
antibiotic residue in food
in human food of animal origin is a seriously regarded pollution in public health surveillance. The residues may arise from systemic administration, or even after absorption from a local site such as the uterus, but the most serious contamination arises from milk from quarters that have been treated for mastitis. It is essential for the safety of the human population, the financial well-being of the farmer and the professional reputation of the veterinarian that antibacterial withdrawal times are observed.
see antimicrobial resistance.
second generation antibiotic
produced by manipulation of the molecular structure of a first generation antibiotic (see above) so that the metabolism and pharmacodynamics of the original compound are significantly altered.
antibiotic sensitivity test
see antimicrobial sensitivity test.
antibiotics vary in their absorption from the alimentary tract, requiring some, e.g. streptomycin, to be given parenterally for systemic effect, freedom from toxicity, the range of bacteria against which they are effective, their capacity to stimulate resistance and whether they are bacteriostatic or bactericidal in their effects. Selection of the most suitable antibiotic to suit a particular circumstance may be guided by an antimicrobial sensitivity test, knowledge of the infection present and the price of the drug. In many instances, because of lack of knowledge of the infection present it is necessary to choose an agent with a broad antibacterial spectrum.
antibiotic withdrawal, antibiotic withholding
see antibacterial withdrawal time.