brittle bones


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os·te·o·gen·e·sis im·per·fec·ta (OI),

, osteogenesis imperfecta congenitaosteogenesis imperfecta tarda
a group of connective tissue disorders of type I collagen, characterized by bone fragility, fractures on trivial trauma, skeletal deformity, blue sclerae, ligament laxity, and hearing loss. The Sillence system, which is a clinical, radiographic, and genetic classification, shows four types; inherited as autosomal dominant, caused by mutation in either the collagen type I alpha-1 gene (COL1A1) on chromosome 17q or the alpha-2 gene (COL1A2) on 7q.
Synonym(s): brittle bones

brittle bones

(1) Osteogenesis imperfecta
(2) Osteoporosis

brittle bones

1. Osteogenesis imperfecta Bones with ↑ osseous fragility, a phenomenon seen in osteogenesis imperfecta, due to genetic defects–eg, point mutation in collagen, type I.
2. Osteoporosis, see there.

os·te·o·gen·e·sis im·per·fec·ta

(OI) (os'tē-ō-jen'ĕ-sis im'pĕr-fek'tă)
Abnormal fragility and plasticity of bone, with recurring fractures on trivial trauma; variable associated features include deformity of long bones, blueness of sclerae, laxity of ligaments, and otosclerosis.
Synonym(s): brittle bones.

brittle bones

A popular term usually applied to bones liable to fracture on minimal force because of loss of structural strength from conditions such as OSTEOPOROSIS or the hereditary disease OSTEOGENESIS IMPERFECTA.

Patient discussion about brittle bones

Q. is their any way to cure osteogenesis imperfecta my son has this bone disorder and can;t stand to see him cry thank you for any help

A. as far as i know- OI is a genetic problem. today there is no cure to genetic problems. there is a big research on gene therapy but there's a long long road before we will see any result..sorry... but there are several treatments that can ease your son's pain, here is a wonderful site that stores a vast amount of information about IO, including recent studies and researches:
http://www.oif.org/site/PageServer

More discussions about brittle bones
References in periodicals archive ?
Brittle bone sufferers all over Teesside and abroad knew and loved her.
While Sonia was still pregnant and living in Letterkenny, Co Donegal, she was told her baby had a brittle bone disorder, Osteogenesis Imperfecta.
We hear a lot about osteoporosis but very little about brittle bones yet they are so similar.
Hens kept in battery cages for long periods develop brittle bones which can lead to fractures and even death.
But doctors say even women in their 30's can experience unpleasant menopausal symptoms like mood swings, weight gain, brittle bones and low libido during extreme PMS or perimenopause.
Q I've got brittle bones (osteoporosis) and I'm on several drugs from my doctor.
Dressed in yellow, black and white, these students hoped to raise awareness for Brittle Bones Disease.
Diane is pictured with other members of the sponsored pub crawl, which was raising money on behalf of an appeal by the children's TV programme Magpie for children suffering with brittle bones.
NERVES are on edge for any parent preparing for the birth of their first child, but none more so than a Birmingham couple who discovered their newborn had brittle bones.
SEVEN-YEAR-OLD Caitlin Gault is an amazing little girl, suffering from brittle bones, her legs broken 24 times.